| Identification | More | [Name]
4-BROMO-2,6-DIFLUOROBENZYLALDEHYDE | [CAS]
537013-51-7 | [Synonyms]
4-BROMO-2,6-DIFLUOROBENZALDEHYDE
4-BROMO-2,6-DIFLUOROBENZYLALDEHYDE | [EINECS(EC#)]
675-098-7 | [Molecular Formula]
C7H3BrF2O | [MDL Number]
MFCD03094459 | [Molecular Weight]
221 | [MOL File]
537013-51-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
76-81 °C | [Boiling point ]
231.4±40.0℃ (760 Torr) | [density ]
1.758±0.06 g/cm3 (20 ºC 760 Torr) | [Fp ]
93.7±27.3℃ | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
powder to crystal | [color ]
White to Light yellow to Light orange | [Sensitive ]
Air Sensitive | [InChI]
InChI=1S/C7H3BrF2O/c8-4-1-6(9)5(3-11)7(10)2-4/h1-3H | [InChIKey]
CZGVAISJIQNQEJ-UHFFFAOYSA-N | [SMILES]
C(=O)C1=C(F)C=C(Br)C=C1F | [CAS DataBase Reference]
537013-51-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301 | [Precautionary statements ]
P301+P310 | [Hazard Codes ]
Xi | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
2811 | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
6.1 | [PackingGroup ]
Ⅲ | [HS Code ]
29130000 |
| Hazard Information | Back Directory | [Uses]
4-BROMO-2,6-DIFLUOROBENZYLALDEHYDE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical production process. | [Synthesis]
n-Butyl lithium (0.64ml, 1.2 mmol) was added drop wise to a solution of diisopropyl amine (0.25 mL, 1.5 mmol) in dry THF at -78°C under nitrogen atmosphere over a period of 5 minutes. The reaction mixture was stirred at -20°C for 30 minutes. To this was added 5-bromo-benzo[b]thiophene (200 mg, 0.938 mmol) in dry THF at -78°C, continued stirring for a further 30 minutes at -78°C, followed by the addition of N-chlorosuccinamide (225 mg, 1.68 mmol) in dry THF at -78°C. The resulting mixture was stirred at room temperature for 2 hours. The reaction was monitored by TLC (100% hexane). The reaction mixture was partitioned between ethyl acetate and saturated ammonium chloride. The organic layer was dried over sodium sulfate and concentrated to afford the crude product. Purification by column chromatography on silica gel (100% hexane) afforded the product. Preparation of Intermediate 4-Bromo-2,6-difluoro-benzaldehyde (I-26a): Using analogous reaction condition and reagents as described in Example 20 for the preparation of 1-20a above, 1-bromo-3,5-difluoro-benzene (2 g, 2.10.36 mmol) in THF was reacted with DMF (1.43 g,19.68 mmol), n-butyl lithium (1.56 ml, 12.4 mmol) and diisopropyl amine (0.57 mL, 15.5 mmol) to afford crude product. Purification by column chromatography on silica gel (2% ethyl acetate in hexane) afforded 1.35 g of the product (61% yield). 1H NMR (CDCl3, 300 MHz): δ 11.5-11.0 (s, 1H), 7.4-7.2 (dd, 2H). | [References]
[1] European Journal of Organic Chemistry, 2017, vol. 2017, # 4, p. 818 - 826
[2] Patent: WO2007/49123, 2007, A1. Location in patent: Page/Page column 69-70
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 23, p. 7100 - 7105
[4] Patent: US2015/57309, 2015, A1. Location in patent: Paragraph 0569
[5] Patent: WO2016/11390, 2016, A1. Location in patent: Page/Page column 268; 269 |
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J & K SCIENTIFIC LTD.
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Alfa Aesar
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Energy Chemical
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Jia Xing Isenchem Co.,Ltd
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