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54-84-2

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54-84-2 Structure

54-84-2 Structure
IdentificationBack Directory
[Name]

CINANSERIN HYDROCHLORIDE
[CAS]

54-84-2
[Synonyms]

DPTC
maptc
sq10,643
Nsc125717
CINANSERIN
Cinnanserin
DPTC HYDROCHLORIDE
CINANSERIN HYDROCHLORIDE
2'-(3-DIMETHYLAMINOPROPYL-THIO)-CINNAMANILIDE HYDROCHLORIDE
DPTC 2'-(3-Dimethylaminopropylthio)cinnamanilide hydrochloride
2’-((3-(dimethylamino)propyl)thio)-cinnamanilidmonohydrochloride
2'-[[3-(Dimethylamino)propyl]thio]cinnamanilide monohydrochloride
N-[2-[[3-(DIMETHYLAMINO)PROPYL]THIO]PHENYL]-3-PHENYL-2-PROPENAMIDE
Cinnamanilide, 2'-[[3-(dimethylamino)propyl]thio]-, monohydrochloride
(E)-N-[2-[3-(dimethylamino)propylsulfanyl]phenyl]-3-phenylprop-2-enamide
n-(2-((3-(dimethylamino)propyl)thio)phenyl)-3-phenyl-2-propenamidmonohyd
N-(2-((3-(Dimethylamino)propyl)thio)phenyl)-3-phenylacrylamide hydrochloride
N-[2-[[3-(DIMETHYLAMINO)PROPYL]THIO]PHENYL]-3-PHENYL-2-PROPENAMIDE HYDROCHLORIDE
2-Propenamide, N-[2-[[3-(dimethylamino)propyl]thio]phenyl]-3-phenyl-, monohydrochloride
[Molecular Formula]

C20H25ClN2OS
[MDL Number]

MFCD00055609
[MOL File]

54-84-2.mol
[Molecular Weight]

376.94
Chemical PropertiesBack Directory
[density ]

1.22 g/cm3
[storage temp. ]

Inert atmosphere,Store in freezer, under -20°C
[solubility ]

DMSO : 125 mg/mL (331.62 mM; Need ultrasonic)
[form ]

Powder
[color ]

Light yellow to yellow
[Water Solubility ]

Soluble to 50 mM in water
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
[HS Code ]

2921490090
Hazard InformationBack Directory
[Uses]

Serotonin inhibitor.
[Application]

Cinanserin Hydrochloride is a useful research chemical. Cinanserin is an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro.
[Definition]

ChEBI: Cinanserin hydrochloride is the hydrochloride salt of cinanserin. It is an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus (SARS-Cov) and reduces virus replication in vitro. It has a role as an antiviral agent, an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor and an anticoronaviral agent. It contains a cinanserin(1+).
[in vivo]

Cinanserin (5 mg/kg; intravenous injection; for 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels. Leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin[2].

Animal Model:Male Wistar rats (250 g) underwent thermal injury[2]
Dosage:5 mg/kg
Administration:Intravenous injection; for 2 hours
Result:Significantly reduced systemic burn edema to shamburn levels..
[IC 50]

5-HT2 Receptor: 41 nM (Ki); 3C-like proteinase
[storage]

Desiccate at RT
Spectrum DetailBack Directory
[Spectrum Detail]

CINANSERIN HYDROCHLORIDE(54-84-2)1HNMR
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