| Identification | Back Directory | [Name]
Isoastilbin | [CAS]
54081-48-0 | [Synonyms]
Isoastilbin
4H-1-Benzopyran-4-one,3-[(6-deoxy-R-Lmannopyranosyl) oxy]-2-(3,4-dihydroxyphenyl)- 2,3-dihydro-5,7-dihydroxy-,(2R,3S)-
4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-, (2R,3S)- | [Molecular Formula]
C21H22O11 | [MOL File]
54081-48-0.mol | [Molecular Weight]
450.39 |
| Chemical Properties | Back Directory | [Melting point ]
278-280 °C (decomp) | [Boiling point ]
801.1±65.0 °C(Predicted) | [density ]
1.74±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [form ]
Solid | [pka]
7.34±0.60(Predicted) | [color ]
White to off-white | [InChIKey]
ZROGCCBNZBKLEL-UQDOWIEGNA-N | [SMILES]
[C@@H]1(C2=CC=C(O)C(O)=C2)OC2=C(C(O)=CC(O)=C2)C(=O)[C@H]1OC1[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O1 |&1:0,20,23,25,27,29,r| | [CAS DataBase Reference]
54081-48-0 |
| Hazard Information | Back Directory | [Description]
Isoastilbin (IA) is a dihydroflavonol glycoside compound, and studies have shown that IA has a good effect on antioxidants. | [Uses]
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research[1][21][3]. | [Biological Activity]
Isoastilbin, a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. It inhibits glucosyltransferase (GTase) with IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. It has neuroprotective, antioxidant, antimicrobial and anti-apoptotic properties and can be used in Alzheimer's disease research. | [target]
IC50: 54.3 μg/mL (Glucosyltransferase (GTase) | [References]
[1] Hong Yu, et al. Protective Roles of Isoastilbin Against Alz heimer's Disease via Nrf2-mediated Antioxidation and anti?apoptosis. Int J Mol Med. 2019 Mar;43(3):1406-1416. DOI:10.3892/ijmm.2019.4058
[2] Harlinda Kuspradini, et al. Antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of taxifolin and some flavanonol rhamnosides from kempas (Koompassia malaccensis) extracts. J. Wood Sci., 2009, 55(4):308-13.
[3] Batubara, Irmanida, et al. Anti-acne and Tyrosinase Inhibition Properties of Taxifolin and Some Flavanonol Rhamnosides from Kempas. Wood Research Journal ,2010, 1(1):45-9. |
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