| Identification | Back Directory | [Name]
4-Methyl-2-(1-piperidinyl)-quinoline | [CAS]
5465-86-1 | [Synonyms]
ML 204
NSC 25850
ML-204;ML204
4-methyl-2-(piperidin-1-yl)quinoline
4-Methyl-2-(1-piperidinyl)-quinoline
Quinoline, 4-methyl-2-(1-piperidinyl)- | [Molecular Formula]
C15H18N2 | [MDL Number]
MFCD00817920 | [MOL File]
5465-86-1.mol | [Molecular Weight]
226.32 |
| Chemical Properties | Back Directory | [Melting point ]
72-73 °C | [Boiling point ]
177-180 °C(Press: 4.5 Torr) | [density ]
1.102±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL at warmed (clear solution) | [form ]
powder | [pka]
7.34±0.61(Predicted) | [color ]
white to beige | [InChI]
1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3 | [InChIKey]
USYRQXDHKXGTCK-UHFFFAOYSA-N | [SMILES]
Cc1cc(nc2ccccc12)N3CCCCC3 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Description]
ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM. | [Uses]
4-Methyl-2-(1-piperidinyl)-quinoline is a potent inhibitor of TRPC4 channels, responsible for various stimulation, muscle response due to interaction with the environment. | [Biochem/physiol Actions]
ML204 is a potent and selective TRPC4 channel inhibitor. | [in vivo]
ML204 (1 mg/kg; s.c.; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice[4].
| Animal Model: | Nonfasted male C57BL/6 (2-3 months)[4] | | Dosage: | 1?mg/kg | | Administration: | Subcutaneous injection, twice a day, for 5 days (prior to LPS injection) | | Result: | Induced mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response. |
| [IC 50]
TRPC4; TRPC5 | [storage]
Store at +4°C | [References]
[1] ERIKO MICHISHITA. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin[J]. Nature, 2008, 452 7186: 492-496. DOI: 10.1038/nature06736 |
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