| Identification | Back Directory | [Name]
12-DEOXYPHORBOL 13-PHENYLACETATE 20-ACETATE | [CAS]
54662-30-5 | [Synonyms]
12-DPPAA
3-acetate9a-phenylacetate
12-deoxyphorbolphenylacetate-20-acetate
12-Deoxyphorbol 13-phenylacate 20-acetate
12-DEOXYPHORBOL 13-PHENYLACETATE 20-ACETATE
(1aR)-3-(Acetyloxymethyl)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα-dihydroxy-1,1,6,8α-tetramethyl-9aα-[(phenylacetyl)oxy]-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one
Benzeneacetic acid ,(1ar,1bs,4ar,7as,7br,8R,9as)-3-((acetyloxy)methyl)-1,1A,1B,4,4A,5,7A,7B,8,9-decahydro-4A,7B-dihydroxy-1,1,6,8-tetramethyl-5-oxo-9ah-cyclopropa(3,4)benz(1,2-E)azulen-9A-yl ester
5H-Cyclopropa(3,4)benz(1,2-E)azulen-5-one, 1,1A-alpha,1B-beta,4,4A,7A-alpha,7B,8,9,9A-decahydro-4A-beta,7B-alpha,9A-alpha-trihydroxy-3-(hydroxymethyl)-1,1,6,8-alpha-tetramethyl-, 3-acetate 9A-phenylacetate | [Molecular Formula]
C30H36O7 | [MDL Number]
MFCD01741294 | [MOL File]
54662-30-5.mol | [Molecular Weight]
508.6 |
| Chemical Properties | Back Directory | [Boiling point ]
556.46°C (rough estimate) | [density ]
1.0979 (rough estimate) | [refractive index ]
1.6810 (estimate) | [storage temp. ]
-20°C | [form ]
oil | [color ]
colorless to light yellow | [InChIKey]
MEDVHSNRBPAIPU-XMOZQXTISA-N | [SMILES]
CC(C1=O)=C[C@]2([H])[C@]1(O)CC(COC(C)=O)=C[C@]3([H])[C@]2(O)[C@H](C)C[C@]4(OC(CC5=CC=CC=C5)=O)[C@H]3C4(C)C |
| Hazard Information | Back Directory | [Uses]
dPPA/phorbol ester 12-deoxyphorbol 13-phenylacetate 20-acetate (DOPPA) may be used as a potent activator of PKC-β:
- to tre at transfected HT-22 cells to promote phosphorylation of p66Shc
- to tre at HT-22 and B12 cells to study its effects on cell viability
- to tre at neurons and measure primary cortical neurons using the 2,5-diphenyl-2H-tetrazolium bromide (MTT) assay
| [Biological Activity]
dPPA is a phorbol ester th at selectively activates the β isotype of PKC. It is approximately 100-fold more potent for PKC-β than the αγ or δ isotypes. PKC family members each have specific functionsbut PKC-β and δ appear to share similar expression profilesand both are involved in regulating apoptosis and B cell activationthus dPPA is a useful tool in determining PKCβ specific signaling events. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
CHEMICAL LAND21
|
| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
|