| Identification | Back Directory | [Name]
HYOCHOLIC ACID | [CAS]
547-75-1 | [Synonyms]
HYOCHOLIC ACID
GAMMA MURICHOLIC
Porcine cholic acid
Hyocholic acid (HCA)
LAMBDA-MURICHOLIC ACID
3-ALPHA,6-ALPHA,7-ALPHA-
HYOCHOLIC ACIDHYOCHOLIC ACID
5β-Cholanic acid-3α,6α,7α-triol
3a,6a,7a-Trihydroxy-5b-cholanic acid
3α,6α,7α-Trihydroxy-5β-cholanic Acid
5B-CHOLAN-24-OIC ACID-3A,6A,7A-TRIOL
3A,6A-7A-TRIHYDROXY-5B-CHOLAN-24-OIC ACID
3α,6α,7α-Trihydroxy-5β-cholan-24-oic acid
5-BETA-CHOLANIC ACID-3-ALPHA, 6-ALPHA, 7-ALPHA-TRIOL
Cholan-24-oic acid, 3,6,7-trihydroxy-, (3α,5β,6α,7α)-
5-BETA-CHOLAN-24-OIC ACID-3-ALPHA,6-ALPHA,7-ALPHA-TRIOL
3-ALPHA,6-ALPHA,7-ALPHA-TRIHYDROXY-5-BETA-CHOLAN-24-OIC ACID
3,6,7-trihydroxy-,(3alpha,5beta,6alpha,7alpha)-cholan-24-oicaci
4-(3,6,7-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
(R)-4-((3R,5R,6R,7S,8S,9S,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
(4R)-4-[(3R,5R,6R,7S,8S,9S,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]valeric acid | [EINECS(EC#)]
208-935-8 | [Molecular Formula]
C24H40O5 | [MDL Number]
MFCD00056519 | [MOL File]
547-75-1.mol | [Molecular Weight]
408.57 |
| Chemical Properties | Back Directory | [Melting point ]
162 °C | [Boiling point ]
565.7±40.0 °C(Predicted) | [density ]
1.184±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Ethanol (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
4.76±0.10(Predicted) | [color ]
Light Brown to Brown | [Optical Rotation]
+5.525 | [InChIKey]
DKPMWHFRUGMUKF-KWXDGCAGSA-N | [SMILES]
O[C@H]1[C@@H]2[C@@H]([C@@]4([C@H]([C@H]1O)C[C@@H](CC4)O)C)CC[C@]3([C@H]2CC[C@@H]3[C@@H](CCC(=O)O)C)C |
| Hazard Information | Back Directory | [Uses]
3α,6α,7α-Trihydroxy-5β-cholanic Acid is one of the bile acids categorizes under muricholic acid, a group of bile acids found in human urine due to its additional hydroxyl groups. The synthesis of 3α,6
α,7α-Trihydroxy-5β-cholanic Acid was shown to be promoted due to overexpression of cholesterol 7α-hydroxylase enzyme. | [Definition]
ChEBI: A trihydroxy-5beta-cholanic acid in which the three hydroxy substituents are located at the 3alpha-, 6alpha- and 7alpha-positions. | [Biological Activity]
Hyocholic acid levels are elevated in plasma and urine samples of patients with cholestatic liver disease and in hepatic cirrhosis. | [in vivo]
Hyocholic Acid (20 mg/kg, p.o.) suppresses BA depletion-induced blood glucose increase in pigs[3].
Hyocholic Acid (100 mg/kg/day, p.o.) improves serum fasting GLP-1 secretion and glucose homeostasis in diabetic mouse models[3].
| Animal Model: | BA depletion pigs[3] | | Dosage: | 20 mg/kg | | Administration: | Oral administration (p.o.) | | Result: | Attenuated the increased blood glucose levels corresponding with GLP-1 decrease. |
| Animal Model: | db/db model, and the high-fat diet and streptozotocin (HFD+STZ) induced diabetic model[3] | | Dosage: | 100 mg/kg/day | | Administration: | Oral administration (p.o.) | | Result: | Improved oral glucose tolerances shown by lower glucose levels.
Increased circulating active GLP-1 levels and fasting insulin levels.
|
| [storage]
Store at -20°C |
|
|