ChemicalBook--->CAS DataBase List--->21967-41-9

21967-41-9

21967-41-9 Structure

21967-41-9 Structure
IdentificationMore
[Name]

Baicalin
[CAS]

21967-41-9
[Synonyms]

BAICALEIN 7-BETA-D-GLUCOPYRANOSIDURONATE HYDRATE
BAICALIN 7-BETA-D-GLUCOPYRANOSIDURONATE HYDRATE
BAICALIN HYDRATE
Baicalin Injection
BAICALIN, 98+% BY HPLC
Bassora
Radix
Baicailin
ASTRAGALIN(KAEMPFEROL-3-O-GLUCOSIDE)(P)
BAICALIN(P)
7-GLUCURONICACID-5,6-DIHYDROXYFLAVONE
BAICALIN WITH HPLC
BAICALIN hplc
5,6-Dihydroxy-4-oxygen-2-phenyl-4H-1-benzopyran-7-beta-D-glucopyranose acid
Baicalein 7-O-glucuronide
Baicalin
BAICALINB-D-GLUCOPYRANOSIDURONIC ACID, 5,6-DIHYDROXY-4-OXO-2-PHENYL-4H-1-BENZOPYRAN-7-YL,
BAICALIN 7-B-D-GLUCOPYRANOSIDURONATE HYDRATE
5,6-Dihydroxy-7-(β-D-glucopyranuronosyloxy)flavone
5,6-Dihydroxyflavon-7-yl β-D-glucopyranosiduronic acid
[EINECS(EC#)]

606-866-1
[Molecular Formula]

C21H18O11
[MDL Number]

MFCD00149302
[Molecular Weight]

446.36
[MOL File]

21967-41-9.mol
Chemical PropertiesBack Directory
[Melting point ]

202-205 °C (dec.) (lit.)
[alpha ]

-85 º (c=1, DMSO)
[Boiling point ]

836.6±65.0 °C(Predicted)
[density ]

1.737±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

solid
[pka]

2.72±0.70(Predicted)
[color ]

Pale Yellow to Yellow
[optical activity]

[α]20/D 85°, c = 1 in DMSO
[Stability:]

Hygroscopic
[InChIKey]

IKIIZLYTISPENI-ZFORQUDYSA-N
[CAS DataBase Reference]

21967-41-9(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
[WGK Germany ]

3
[RTECS ]

LZ5776910
[HS Code ]

29329900
Questions And AnswerBack Directory
[Description]

Baicalin, the active compound of the Blue Skullcap, is a type of flavonoid.
Baicalin exhibits anti-inflammatory, anti-tumor, anti-angiogenic, anti-oxidant, anti-apoptotic, anti-viral, and antibacterial properties. It could be used for the treatment of autoimmune diseases and several cancers (hepatitis B virus (HBV)-infected liver cancer,  hepatic cancer, cervical cancer, etc.). It can be used to treat against dengue virus. It is used in preparation of the drug for treating and rescuing ricin poisoning. Due to its anti-apoptotic effect which can protect PC-12 cells from oxidative stress, baicalin can be used for reducing stress and helping to promote healthy sleep cycles.
[References]

[1] Ehsan Moghaddam, Boon-Teong Teoh, Sing-Sin Sam, Rafidah Lani, Pouya Hassandarvish, Zamri Chik, Andrew Yueh, Sazaly Abubakar, Keivan Zandi (2014) Baicalin, a metabolite of baicalein with antiviral activity against dengue virus, Scientific Reports, 4, 5452
[2] Yuan Zhang, Xing Li, Bogoljub Ciric, Cun-Gen Ma, Bruno Gran, Abdolmohamad Rostami, Guang-Xian Zhang (2015) Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway, Scientific Reports, 5, 17407
[3] Patent US 20160361334 A1: Application of baicalin in preparation of drug for treating ricin poisoning
Hazard InformationBack Directory
[Chemical Properties]

Light yellow powder
[Physical properties]

Appearance: light yellow crystalline powder at room temperature. Solubility: insoluble in methanol, ethanol, and acetone; slightly soluble in chloroform and nitrobenzene; almost insoluble in water; soluble in hot acetic acid. Melting point: 202–205?°C.
[History]

The chemical research of the genus Scutellaria began in 1889. Baicalein (scutellarein) is the first flavonoid isolated from Vietnam radix scutellariae (S. altissima) in 1910. In 1922, Shibata Gui Tai and his collaborators isolated and obtained baicalin, baicalein, wogonin, and benzoic acid from Scutellaria baicalensis.
Among the flavonoids in Scutellaria baicalensis, the content of baicalein is the highest. Its official name is baikeli. Baicalin is formed by the combination of baicalein and one molecule of glucuronic acid. Both baicalein and baicalin exist in Scutellaria baicalensis. Studies showed that baicalein could be transferred into baicalin and other metabolites in the blood. However, baicalin by oral is hardly absorbed. Baicalein can be absorbed and also rapidly converted into baicalin.
At present, there are a variety of mature extraction methods for obtaining baicalin and baicalein from Scutellaria baicalensis. Due to the poor water solubility, oral preparation of baicalin is mostly used in clinical practice. Research showed that baicalin had a significant first pass effect, which led to its low bioavailability. Baicalin-metal complexes formed by the combination of baicalin and metal ions were found to enhance bioavailability and increase pharmacological activities. In addition, the preparation of ester-type prednisone was easily hydrolyzed by esterase and could improve the lipid solubility of baicalin.
[Uses]

diuretic, prolyl endopeptidase inhibitor, antineoplastic
[Definition]

ChEBI: The glycosyloxyflavone which is the 7-O-glucuronide of baicalein.
[Indications]

Baicalin is mainly used for the adjuvant therapy of acute and chronic hepatitis and persistent hepatitis.
[General Description]

Baicalin is a key flavonoid found in the roots of Scutellaria baicalensis. It is known to have different biological activities, such as anti-oxidative, anti-inflammatory, antitumor and anti-apoptotic activities.
[Pharmacology]

Pharmacological studies showed that both baicalein and baicalin had a variety of pharmacological effects such as antibacterial, antiviral, removal of oxygen free radicals, antioxidant, antipyretic, analgesic, anti-inflammatory, antitumor, cardiovascular protecting, cerebrovascular and neuron protecting, liver protecting, and prevention or treatment of diabetes and its complications
1. Antibacterial and antiviral effects: Scutellaria baicalensis was reported to have growth inhibitory effect on a variety of Gram-negative bacteria, Gram-positive bacteria, and spirochetes, showing a broad antibacterial spectrum. Baicalein was regarded as the main ingredient in Scutellaria baicalensis to play the antibacterial effect. The IC50 of baicalein on Escherichia coli was about 0.29?mmol·L?1 , and the minimum inhibitory concentration (MICs) of Candida albicans was 264?μg·mL?1 . The survival time of mice infected with influenza virus was significantly extended by the gastric irrigation of baicalin at a dose of 0.96–1.5?g·kg?1.
2. Antitumor effect: In vitro and in vivo experimental results showed that both baicalein and baicalin had obvious antitumor activity, and the mechanism involved the inhibition of tumor cell proliferation, invasion and metastasis, induction of tumor cell apoptosis, suppression of neovascularization, and enhanced tumor cell chemotherapy sensitivity. Baicalein was found to inhibit theproliferation of rat bladder cancer MBT-2 cells and induce apoptosis, and its IC50 was 0.43?μmol·L?1 . In bladder cancer model formed by injection of MBT-2 cells into C3H/HeN nude mice, the formed tumor in mouse given baicalein 0.05– 0.1?mg·day?1 for ten consecutive days was significantly smaller than that of the control group. A 50–200?μmol·L?1 baicalein could inhibit the proliferation of human prostate cancer DU2145 and PC3 cells, human umbilical vein endothelial cell proliferation, and the formation of buds and vascular structure in a dosedependent manner. Baicalein could also inhibit human breast cancer cell MDAMB-231 adhesion, metastasis, and invasion, in a dose-dependent manner in the range of 2–50?μmol·L?1 . Moreover, a dose of 100?μg·mL?1 could also reverse the resistance of ovarian cancer cell line A2780/ADM.?This reversal may be associated with a decrease in P-gp drug efflux and increased intracellular drug concentration
3. Antipyretic, analgesic, and anti-inflammatory effects: Both baicalein and baicalin can play antipyretic, analgesic, and anti-inflammatory effects by interfering with the arachidonic acid metabolism pathway, inhibiting the activity of nuclear factor, and suppressing the secretion and release. In rats, intraperitoneal injection of baicalin at a dose of 4.5?mg·kg?1 could exert antipyretic effect; the body temperature of the endotoxin-induced fever rabbits was heavily reduced after intravenous administration of baicalin at a dose of 20?mg·kg?1 ; baicalein at a dose of 20?mg·kg?1 (iv) could improve the hemodynamics and heart rate and reduce the mortality and the leukocyte infiltration into the liver and lung tissues in endotoxic shock rats (LPS 10?mg·kg?1 , iv).
4. Scavenging oxygen free radicals and antioxidant effects: Both baicalein and baicalin were found to have strong scavenging effects on hydroxyl radicals, superoxide anion (O2?), alkane peroxy radicals, and DPPH free radicals. A 25–100?μmol·L?1 baicalein can inhibit H2O2-induced RAW264.7 cell apoptosis and diploid formation.
5. Liver protection: Both baicalein and baicalin were found to have protective effect on the liver injured by a variety of causes, and the mechanism was related to their function of antioxidant and inhibition of the secretion of inflammatory mediators. It was found that intraperitoneal injection of baicalin at a dose of 50–200?mg·kg?1 had protective effect on CCl4-induced acute liver injury mice. Intraperitoneal injection of baicalin at a dose of 70?mg·kg?1 could improve CCl4- induced chronic liver fibrosis in mice. In addition, gavage of baicalin to mice at a dose of 50–150?mg·kg?1 significantly reduced the immune liver injury caused by D-GalN and LPS.
6. Treatment or prevention of diabetes and its complications: Baicalein was found to have effects of protecting the islet tissue and improving kidney function and retinopathy in diabetic rats, and the mechanism might ascribe to its function on reducing the inflammatory response and inhibition of oxidative stress injury. Streptozotocin-induced diabetic rats were found to have decreased blood glucose concentration and the improvement of islet tissue damage after gavage of baicalin at a dose of 25–100? mg·kg?1 . After gavage of baicalin at a dose of 80–120?mg·kg?1 for 12?weeks, an obvious protective effect on the kidney tissueof diabetic rats was observed. In addition, the administration of baicalein at a dose of 150?mg·kg?1 day?1 was found to ameliorate diabetic retinopathy.
7. Cardiovascular and cerebrovascular protective effects: In vitro experiment results showed that Scutellaria baicalensis had cardiovascular protective effects such as dilating blood vessels, counteracting high blood pressure, protecting heart and endothelial cells, and anti-atherosclerosis. Baicalein did not affect normal blood pressure in rats but could reduce blood pressure in hypertensive rats. Baicalin at concentration of 0.5 and 2?μmol·L?1 was found to decrease the contractile tension of isolated rat aorta induced by norepinephrine, KCl, and CaCl2, shifting the reaction curve from the left to the right side and reducing the maximal effect. It could also significantly inhibit the norepinephrine-dependent contraction induced by intracellular and outside Ca2+. Baicalein had protective effect on myocardial ischemia and reperfusion injury, and this effect was stronger than baicalin. Intravenous injection of baicalein at a dose of 10?mg·kg?1 could improve the contraction of myocardium in endotoxic shock rats.
8. Neuroprotective effect: Baicalein had a good neuroprotective effect. It could suppress nerve injury and apoptosis by inhibiting the inflammatory response induced by glial cell, anti-free radicals, and protection of mitochondria. Administration of baicalein at a dose of 200?mg·kg?1 could relieve 6-OHDAinduced muscle tremor injury in rats. Gavage of baicalein at a dose of 200?mg·kg?1 could improve the recovery of motor function in Parkinson model mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Intraperitoneal injection of baicalein at a dose of 30?mg·kg?1 reduced the neurological deficit score of MCAO model rats, decreasing brain water content and cerebral infarction volume, which indicated that baicalein had a protective effect on the neurological function of rats with focal cerebral ischemia.
9. Other effects: Baicalein and baicalin were also reported to have other pharmacological effects such as enhancing immune function.
[Clinical Use]

In clinical, baicalin is mainly used as the adjuvant therapy for acute and chronic hepatitis and persistent hepatitis. Baicalin was shown to reduce the expression of hepatitis B surface antigen, e antigen and the core antigen, and inhibited hepatitis B virus DNA replication. Reduced serum alanine aminotransferase level was observed in hepatitis patient treated with baicalin, and other liver function indexes were also found to be improved. No adverse reactions about baicalin have been reported. In addition, baicalin was reported to treat early diabetic nephropathy and alleviate the symptoms of diabetic neuropathy
As one of the antimicrobial components of Scutellaria baicalensis, eye drops containing 3% baicalin are used clinically in the treatment of trachoma, with the similar curative effect as rifampicin.
Moreover, baicalein is used clinically for the treatment of enteritis and dysentery.
[Enzyme inhibitor]

This baicalein glucuronide (FW = 446.36 g/mol; CAS 21967-41-9), also known as 5,6-dihydroxy-4-oxygen-2-phenyl-4H-1-benzopyran-7-b-D glucopyranose acid, is a flavone prodrug found in the Chinese medicinal herb Huang-chin (Scutellaria baicalensis) that is hydrolyzed to baicalein (See Baicalein). Baicalin is a slow, tight-binding inhibitor of Jack Bean urease, rapidly forming initial BA-urease complex (Ki = 3.9 × 10–3 M) that slowly isomerizes to the final complex (overall inhibition constant of Ki* = 0.15 × 10 μM. Inhibition can be reversed by dithiothreitol but not dilution of substrate. Baicalin also inhibits prolyl oligopeptidase, a cytosolic serine peptidase that hydrolyzes proline-containing peptides at the carboxy terminus of proline residues and is associated with schizophrenia, bipolar affective disorder, and related neuropsychiatric disorders. (See Pramiracetam)
Spectrum DetailBack Directory
[Spectrum Detail]

Baicalin(21967-41-9)MS
Baicalin(21967-41-9)1HNMR
Baicalin(21967-41-9)13CNMR
Baicalin(21967-41-9)IR1
Baicalin(21967-41-9)IR2
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

21967-41-9(sigmaaldrich)
[TCI AMERICA]

Baicalin,>90.0%(T)(21967-41-9)
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