| Identification | Back Directory | [Name]
Chlorozotocin | [CAS]
54749-90-5 | [Synonyms]
CZT
DCNU
CHLZ
CCRIS 879
NCS-178248
NCS-D-254157
Chlorozotocin
2-(3-(2-CHLOROETHYL)-3-NITROSOUREIDO)-D-GLUCOPYRANOSE
D-Glucose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy- | [Molecular Formula]
C9H16ClN3O7 | [MDL Number]
MFCD00866505 | [MOL File]
54749-90-5.mol | [Molecular Weight]
313.69 |
| Chemical Properties | Back Directory | [Melting point ]
147-148° (dec with the evolution of gas); mp 140-141° (dec) | [Boiling point ]
119.3°C (rough estimate) | [density ]
1.6475 (rough estimate) | [refractive index ]
1.6000 (estimate) | [pka]
9.08±0.46(Predicted) | [IARC]
2A (Vol. 50) 1990 | [EPA Substance Registry System]
Chlorozotocin (54749-90-5) |
| Safety Data | Back Directory | [RIDADR ]
3249 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Safety Profile]
Confirmed carcinogen
with experimental carcinogenic and
tumorigenic data. Poison by subcutaneous,
intravenous, and intraperitoneal routes.
Human systemic effects by intravenous
route: anorexia, leukopenia, nausea or
vomiting, thrombocytopenia. Mutation data
reported. When heated to decomposition it
emits very toxic fumes of Cland NOx. See
also NITROSAMINES. | [Hazardous Substances Data]
54749-90-5(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Chemical Properties]
Chlorozotocin is a nitrosourea compound that exists as ivory-coloredcrystals at room temperature. It is soluble in water and is stable in solution at room temperature for up to 3 hours and under refrigeration for 24 hours. The powder form of chlorozotocin is stable under refrigeration for two years. The spontaneous, nonenzymatic degradation of chlorozotocin results in formation of DNA-alkylating and protein-carbamoylating moieties (Chabner et al. 2001). | [Uses]
Chlorozotocin is a cytostatic agent that has been used to treat melanoma and multiple myeloma and cancer of the stomach, large intestine, pancreas, and lung (IARC 1990). | [Definition]
ChEBI: Chlorozotocin is an amino sugar. | [Carcinogenicity]
Chlorozotocin is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals and because it is a member of a well-defined, structurally related class of substances listed in the Report on Carcinogensas either known to be a human carcinogen or reasonably anticipated to be a human carcinogen. |
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