| Identification | More | [Name]
4-N-BOC-AMINOPHENOL | [CAS]
54840-15-2 | [Synonyms]
4-(BOC-AMINO)PHENOL
4-N-BOC-AMINOPHENOL
N-BOC-4-HYDROXY ANILINE
N-Boc-4-hydroxyaniline 97%
tert-Butyl p-hydroxycarbanilate
tert-butyl 4-hydroxyphenylcarbamate
tert-Butyl N-(4-hydroxyphenyl)carbamate
1,1-DiMethylethyl (4-hydroxyphenyl)carbaMate
(4-HYDROXY-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER
Carbamic acid, N-(4-hydroxyphenyl)-, 1,1-dimethylethyl ester
Carbamic acid, (4-hydroxyphenyl)-, 1,1-dimethylethyl ester (9CI) | [Molecular Formula]
C11H15NO3 | [MDL Number]
MFCD00226573 | [Molecular Weight]
209.24 | [MOL File]
54840-15-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
143-147 °C(lit.) | [Boiling point ]
288.7±23.0 °C(Predicted) | [density ]
1.182±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [pka]
10.13±0.26(Predicted) | [Appearance]
White to off-white Solid | [Water Solubility ]
Slightly soluble in water. | [InChI]
InChI=1S/C11H15NO3/c1-11(2,3)15-10(14)12-8-4-6-9(13)7-5-8/h4-7,13H,1-3H3,(H,12,14) | [InChIKey]
YRQMBQUMJFVZLF-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)NC1=CC=C(O)C=C1 | [CAS DataBase Reference]
54840-15-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R43:May cause sensitization by skin contact. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
4-(Boc-amino)phenol, is used to protect amine in the solid phase synthesis of peptides, used to produce [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-carbamic acid tert-butyl ester at ambient temperature. This reaction will need reagent imidazole and solvent dimethylformamide, CH2Cl2. | [Synthesis]
General procedure for the synthesis of oxycarbonyloxy-4-hydroxyaniline from di-tert-butyl dicarbonate and 4-aminophenol: Di-tert-butyl dicarbonate (24.07 g, 110.3 mmol) was slowly added to a methanol (200 mL) solution containing 4-aminophenol (10.97 g, 100.5 mmol) and triethylamine (30 mL). The reaction mixture was stirred at room temperature (22°C) for 14 hours. After completion of the reaction, the solvent was removed by rotary evaporation. The residue was dissolved in ethyl acetate (250 mL) and extracted with 0.25N aqueous hydrochloric acid (100 mL). The organic phase was separated and washed sequentially with saturated aqueous ammonium chloride solution (3 x 50 mL) and dried over anhydrous sodium sulfate. Finally, the solvent was removed by rotary evaporation to give the white solid product oxocarbonyl-4-hydroxyaniline (20.91 g, 100% yield, ESI-MS (m/z) 208.1 [M-H]-). | [References]
[1] Patent: EP1609789, 2005, A1. Location in patent: Page/Page column 12
[2] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1260 - 1264
[3] Chemical Communications, 2013, vol. 49, # 51, p. 5757 - 5759
[4] Organic Letters, 2016, vol. 18, # 21, p. 5728 - 5731
[5] Comptes Rendus Chimie, 2013, vol. 16, # 11, p. 962 - 966 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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