| Identification | Back Directory | [Name]
ERGOLIDE | [CAS]
54999-07-4 | [Synonyms]
ERGOLIDE
Dihydrobigelovin
ERGOLIDE USP/EP/BP
(3aR,7aα,9aβ)-4α-Acetyloxy-3-methylene-4aβ,8α-dimethyldecahydroazuleno[6,5-b]furan-2,5-dione
Azuleno[6,5-b]furan-2,5-dione, 4-(acetyloxy)decahydro-4a,8-dimethyl-3-methylene-, (3aR,4S,4aR,7aS,8R,9aS)- | [Molecular Formula]
C17H22O5 | [MDL Number]
MFCD03427705 | [MOL File]
54999-07-4.mol | [Molecular Weight]
306.35 |
| Hazard Information | Back Directory | [Uses]
Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB[1]. | [Definition]
ChEBI: Ergolide is a sesquiterpene lactone that is decahydroazuleno[6,5-b]furan-2,5-dione substituted by methyl groups at positions 4a and 8, a methylidene group at position 3 and an acetyloxy group at position 4. It has been isolated from the aerial parts of Inula hupehensis. It has a role as a metabolite, an anti-inflammatory agent, a plant metabolite, an antineoplastic agent and a NF-kappaB inhibitor. It is a gamma-lactone, a cyclic ketone, an acetate ester, an organic heterotricyclic compound and a sesquiterpene lactone. | [IC 50]
NF-κB | [References]
[1] Whan Han J, et al. Ergolide, sesquiterpene lactone from Inula britannica, inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-kappaB. Br J Pharmacol. 2001 Jun;133(4):503-12. DOI:10.1038/sj.bjp.0704099 |
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cjbscvictory
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Bide Pharmatech Ltd.
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