| Identification | Back Directory | [Name]
lupanine | [CAS]
550-90-3 | [Synonyms]
Lupanin
lupanine
d-Lupanine
LUPANINE(SH)
2-Oxosparteine
(7aβ,14aα)-Dodecahydro-7α,14α-methano-4H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocin-4-one | [Molecular Formula]
C15H24N2O | [MDL Number]
MFCD00870094 | [MOL File]
550-90-3.mol | [Molecular Weight]
248.368 |
| Chemical Properties | Back Directory | [Melting point ]
40-44° | [alpha ]
D25 +84° (c = 4.8 in alc) | [Boiling point ]
bp3 190-193° | [density ]
0.9789 (rough estimate) | [refractive index ]
nD24 1.5444 | [form ]
Liquid | [pka]
9.47±0.20(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Definition]
ChEBI: The delta-lactam obtained by formal oxidation at the 2-position of sparteine. The major alkaloid from the seeds of Lupinus exaltatus, L. mexicanus and L. rotundiflorus, it is among the most important of the tetracyc
ic quinolizidine alkaloids. | [Uses]
(+)-Lupanine is used in biological studies with quinolizidine alkaloids in seeds of lupin genotypes of different origins. | [in vivo]
Lupanine (100-300 mg/kg for i.p.; 175-700 mg/kg for p.o.) is much less toxic in one single injection in EOPS male Swiss mice (20-22 g) and Hartley guinea-pigs (400-500 g)[1].
Lupanine (1-7.5 mg/kg; i.v.) is more efficient than Sparteine for antagonizing secondary reflex hypertension in carotid occlusion and hypotension resulting from the stimulation of the pneumogastric nerve in both the cat and the dog[1].
Lupanine has an inhibitory action on nicotinic type hypertension produced by injection of Acetylcholine (500 p.g/kg i.v.) in the Atropine-treated dog[1].
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| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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