| Identification | Back Directory | [Name]
Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride | [CAS]
55266-18-7 | [Synonyms]
Mn(III)TBAP (chloride)
Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride
Manganese(III) meso-tetra(4-carboxyphenyl)porphine chloride
5,10,15,20-Tetrakis(4-carboxyphenyl)porphyrin-Mn(III) chloride (MnTBAP) | [Molecular Formula]
C48H28ClMnN4O8 | [MDL Number]
MFCD06227760 | [MOL File]
55266-18-7.mol | [Molecular Weight]
879.149 |
| Chemical Properties | Back Directory | [storage temp. ]
-20C | [solubility ]
Soluble in 0.1M NaOH | [form ]
Brown solid | [color ]
Black | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in 0.1M NaOH may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Description]
MnTBAP (55266-18-7) is a superoxide dismutase (SOD) mimetic. Potent peroxynitrite scavenger but does not scavenge nitric oxide. | [Uses]
MnTBAP chloride is a cell permeable superoxide dismutase mimetic and peroxynitrite scavenger. | [General Description]
Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 μM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO). | [Biochem/physiol Actions]
Cell permeable: yes | [in vivo]
MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice[1]. | Animal Model: | C57BL/6J mice with 5/6 nephrectomy (Nx)[1] | | Dosage: | 10?mg/kg | | Administration: | IP; three times per week for twelve weeks | | Result: | Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.
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| [IC 50]
NFκB | [storage]
Store at -20°C | [References]
1) Szabo et al. (1996), Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial resporation in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger; FEBS Lett., 381 82
2) Faulkner et al. (1994), Stable MN(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo; J. Biol. Chem., 269 23471 |
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