| Identification | More | [Name]
1,2,3,4-Tetrahydroquinolin-2-one | [CAS]
553-03-7 | [Synonyms]
1,2,3,4-Tetrahydroquinolin-2-one
2-OXO-1,2,3,4-TETRAHYDROQUINOLINE
2-OXO-1,3,4-TRIHYDROQUINOLINE
3,4-DIHYDRO-1H-QUINOLIN-2-ONE
3,4-DIHYDRO-2(1H)-QUINOLINONE
3,4-DIHYDRO-2(1H)-QUINOLONE
3,4-DIHYDRO-2(H)-QUINOLINE
DIHYDROCARBOSTYRIL
HYDROCARBOSTYRIL
3,4-Dihydrocarbostyril
dihydro-α-quinolone
o-aminohydrocinnamic acid lactam
3,4-DIHYDRO-1H-QUINOLIN-2-ONE, 99+%
2-Oxo-1,2,3,4-tetrahydroquinoline, 3,4-Dihydrocarbostyril
1,2,3,4-Tetrahydro-2(1H)-quinolinone
1,2,3,4-Tetrahydro-2-oxoquinoline
3,4-Dihydro-2-quinolinone
1,2,3,4-Tetrahydroquinoline-2-one | [EINECS(EC#)]
621-863-5 | [Molecular Formula]
C9H9NO | [MDL Number]
MFCD00016722 | [Molecular Weight]
147.17 | [MOL File]
553-03-7.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-white crystalline powder | [Melting point ]
165-167 °C (lit.) | [Boiling point ]
267.28°C (rough estimate) | [density ]
1.1135 (rough estimate) | [refractive index ]
1.5200 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml | [form ]
Crystalline Powder | [pka]
14.76±0.20(Predicted) | [color ]
Off-white | [Water Solubility ]
Slightly soluble in water. | [Sensitive ]
Light Sensitive | [Merck ]
13,4800 | [InChI]
InChI=1S/C9H9NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-4H,5-6H2,(H,10,11) | [InChIKey]
TZOYXRMEFDYWDQ-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=CC=C2)CCC1=O | [CAS DataBase Reference]
553-03-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS07,GHS06 | [Signal word ]
Warning | [Hazard statements ]
H301-H302-H315-H317-H319-H335 | [Precautionary statements ]
P280a-P301+P310a-P405-P501a-P261-P280-P305+P351+P338 | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R43:May cause sensitization by skin contact. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
2811 | [WGK Germany ]
2
| [Hazard Note ]
Irritant | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29337900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white crystalline powder | [Uses]
3,4-Dihydro-2(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments. | [Uses]
3,4-Dihydro-2-(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments. It is used to prepare potent bicyclic peptide deformylase inhibitors with antibacterial effects. It is also used to synthesize substituted iminopiperidines as inhibitors of human nitric oxide synthase isoforms. | [Definition]
ChEBI: 3,4-Dihydro-2(1H)-quinolinone is a member of quinolines. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 89, p. 7131, 1967 DOI: 10.1021/ja01002a061
Tetrahedron Letters, 36, p. 125, 1995 DOI: 10.1016/0040-4039(94)02191-D | [General Description]
Series of 3,4-dihydro-2(1H)-quinolinone derivatives having sigma-1 receptor (σ1R) antagonist activity have been synthesized. 3,4-dihydro-2((1)H)-quinolinones have been synthesized using N-(1′-alkoxy)cyclopropyl-2-haloanilines as starting reagent. Cyclopropane ring expansion in the presence of palladium catalyst is the major step involved in the synthesis. Library of 3,4-dihydro-2(1H)-quinolinones have been synthesized through the rearrangement of β-lactam intermediates on the solid-phase |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Anichem Inc.
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0512-69369885 |
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www.chemicalbook.com/ShowSupplierProductsList15883/0_EN.htm |
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