| Identification | Back Directory | [Name]
atherospermine | [CAS]
5531-98-6 | [Synonyms]
atherospermine
Atherosperminine
N,N-Dimethyl-3,4-dimethoxyphenanthrene-1-ethanamine
3,4-Dimethoxy-N,N-dimethyl-1-phenanthreneethanamine
1-Phenanthreneethanamine, 3,4-dimethoxy-N,N-dimethyl- | [Molecular Formula]
C20H23NO2 | [MOL File]
5531-98-6.mol | [Molecular Weight]
309.4 |
| Chemical Properties | Back Directory | [Melting point ]
199 °C | [Boiling point ]
466.1±35.0 °C(Predicted) | [density ]
1.109±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [pka]
9.15±0.28(Predicted) |
| Hazard Information | Back Directory | [Uses]
Atherosperminine (Atherospermine) is a nature occurring alkaloid, has antiplasmodial activities in vitro, with an IC50 of 5.80 μM. Atherosperminine is a good reductant with the ability to chelate metals. Atherosperminine has scavenging activity towards the free radical DPPH, with an IC50 of 29.56 μg/mL. Atherosperminine exerts a non-specific relaxant effect on the trachealis[1]. | [Definition]
ChEBI:Atherosperminine is an alkaloid. | [IC 50]
Plasmodium | [storage]
Store at -20°C | [References]
[1] Ayu Afiqah Nasrullah, et al. Antiplasmodial Alkaloids from the Bark of Cryptocarya nigra (Lauraceae). Molecules. 2013 Jul; 18(7): 8009–8017. DOI:10.3390/molecules18078009
[2] C H Lin, et al. The relaxant actions on guinea-pig trachealis of atherosperminine isolated from Fissistigma. Eur J Pharmacol. 1993 Jun 11;237(1):109-16. DOI:10.1016/0014-2999(93)90099-4 |
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