| Identification | Back Directory | [Name]
Jujuboside A | [CAS]
55466-04-1 | [Synonyms]
JUJUBOSIDE A
Jujuboside A USP/EP/BP
Jujuboside A 55466-04-1
JUJUBOSIDE A, 98.0% BY HPLC
Ziziphus jujuba Mill. Var
2)]-b-D-glucopyranosyl-(1®
6)-O-[b-D-xylopyranosyl-(1®
2)-O-[O-b-D-glucopyranosyl-(1®
JUJUBOSIDE A, ≥1% BY HPLC JUJUBA PLANT EXTRACT
α-L-Arabinopyranoside, (3β,16β,23R)-16,23:16,30
glucopyranosyl-(1→6)-O-[β-D-xylopyranosyl-(1→2)]-β-D-glucopyranosyl-(1→3)]-
-diepoxy-20-hydroxydammar-24-en-3-ylO-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[O-β-D-
Jujuboside A, 98%, from Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow
a-L-Arabinopyranoside, (3b,16b,23R)-16,23:16,30-diepoxy-20-hydroxydaMMar-24-en-3-ylO-6-deoxy-a-L-Mannopyranosyl-(1®
(16S,20S,23R)-16,23:16,30-Diepoxy-3β-[2-O-(6-deoxy-α-L-mannopyranosyl)-3-O-[6-O-(β-D-glucopyranosyl)-2-O-(β-D-xylopyranosyl)-β-D-glucopyranosyl]-α-L-arabinopyranosyloxy]-5α-dammar-24-en-20-ol
α-L-Arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[O-β-D-glucopyranosyl-(1→6)-O-[β-D-xylopyranosyl-(1→2)]-β-D-glucopyranosyl-(1→3)]-
O-6-Deoxy-a-L-mannopyranosyl-(1(r)2)-O-[O-b-D-glucopyranosyl-(1(r)6)-O-[b-D-xylopyranosyl-(1(r)2)]-b-D-glucopyranosyl-(1(r)3)]-(3b,16b,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl-a-L-arabinopyranoside | [Molecular Formula]
C58H94O26 | [MDL Number]
MFCD03427709 | [MOL File]
55466-04-1.mol | [Molecular Weight]
1207.35 |
| Chemical Properties | Back Directory | [Melting point ]
222-225°C | [density ]
1.50 | [storage temp. ]
2-8°C | [solubility ]
H2O : 50 mg/mL (41.41 mM; Need ultrasonic) | [form ]
powder | [pka]
12.81±0.70(Predicted) | [color ]
White-beige | [biological source]
plant (Semen Ziziphus spinosa) | [Major Application]
metabolomics
vitamins, nutraceuticals, and natural products | [InChIKey]
KVKRFLVYJLIZFD-OWQSYLKINA-N | [LogP]
-0.194 (est) |
| Safety Data | Back Directory | [Safety Statements ]
24/25 | [WGK Germany ]
WGK 3 | [HS Code ]
29389090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, easily soluble in methanol, almost insoluble in ether, derived from sour jujube seeds. | [Definition]
ChEBI: Jujuboside A is a triterpenoid. | [General Description]
Jujuboside A (JuA) is a saponin isolated from Semen Ziziphus spinosa (SZS) used in Traditional Chinese Medicine. | [Biochem/physiol Actions]
Jujuboside A has been shown to be a major hypnotic-sedative and is used for treating insomnia and anxiety. | [Synthesis]
Preparation of high-purity Jujuboside A reference standard: A. Ethanol extraction of sour jujube seed. B. Enrichment on macroporous resin (water and low-conc. ethanol remove impurities, 50-65% ethanol elutes the target). C. n-Butanol extraction. D. Medium | [in vivo]
During daytime (9:00-15:00), jujubosides significantly increases the total sleep and rapid eye movement (REM) sleep without significant influence on non-REM (NREM) sleep. During nighttime (21:00-3:00), jujubosides significantly increases the total sleep and NREM sleep especially the light sleep while shows no significant effect on REM sleep and slow wave sleep (SWS)[3]. Intracerebroventricular treatment with Jujuboside A significantly mitigates learning and memory impairment in mice induced by Aβ1–42 as measured by the Y-maze, active avoidance and Morris water maze. Intracerebroventricular treatment with Jujuboside A reduces the level of Aβ1–42 in hippocampus, significantly inhibits the activities of acetylcholinesterase (AChE) and NO, and decreases the amount of the increased malondialdehyde (MDA) in the hippocampus and cerebral cortex of mice treated with intracerebroventricular injection of Aβ1–42[4]. |
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China Langchem Inc.
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0086-21-58956006 |
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www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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