| Identification | Back Directory | [Name]
CAROVERINEHYDROCHLORIDE | [CAS]
55750-05-5 | [Synonyms]
p 201-1
CAROVERINEHYDROCHLORIDE
Caroverine hydrochloride >=98% (HPLC), solid
1-Diethylaminoethyl-3-(p-methoxybenzyl)-2-quinoxaone hydrochloride
1-(2-diethylaminoethyl)-3-[(4-methoxyphenyl)methyl]quinoxalin-2-one
2(1H)-Quinoxalinone, 1-(2-diethylamino)ethyl-3-(4-methoxybenzyl)-, hydrochloride
1-[2-(diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]quinoxalin-2-one,hydrochloride
1-(2-Diethylamino)ethyl-3-((4-methoxyphenyl)methyl)-2(1H)-quinoxalinone hydrochloride
1-[2-(Diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]-2(1H)-quinoxalinone monohydrochloride
NMDA,glutamate,calcium,Tinnex,tinnitus,vasorelaxant,antioxidant,Inhibitor,iGluR,inner,inhibit,Caroverine hydrochloride,ear,Ionotropic glutamate receptors,AMPA,Caroverine | [Molecular Formula]
C22H27N3O2 | [MDL Number]
MFCD01684929 | [MOL File]
55750-05-5.mol |
| Hazard Information | Back Directory | [Uses]
Caroverine hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus[1][2][3]. | [in vivo]
Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat[4]. | Animal Model: | Sprague-Dawley rats of either sex (250-300 g) received impulse noise exposure[4] | | Dosage: | 1.44 mg/rat | | Administration: | 20 mg/mL; s.c. 1.0 mL/h for 72 h | | Result: | Significantly protected the cochlea against impulse noise trauma. |
| [storage]
Store at -20°C | [References]
[1] Chen Z, et, al. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs. Audiol Neurootol. Jan-Feb 2003;8(1):49-56. DOI:10.1159/000067893
[2] Denk DM, et, al. Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol. 1997 Nov;117(6):825-30. DOI:10.3109/00016489709114208
[3] Ishida Y, et, al. Vasorelaxant action of caroverine fumarate (a quinoxaline derivative), a calcium-blocking agent. Br J Pharmacol. 1980;71(1):343-8. DOI:10.1111/j.1476-5381.1980.tb10945.x
[4] Duan M, et, al. Low-dose, long-term caroverine administration attenuates impulse noise-induced hearing loss in the rat. Acta Otolaryngol. 2006 Dec;126(11):1140-7. DOI:10.1080/00016480500540519 |
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| Company Name: |
Flax Laboratories
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| Tel: |
+91-9867665132 |
| Website: |
www.flaxlaboratories.com |
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