| Identification | More | [Name]
2-FLUORO-5-HYDROXYPYRIDINE | [CAS]
55758-32-2 | [Synonyms]
2-FLUORO-5-HYDROXYPYRIDINE
6-FLUORO-3-HYDROXYPYRIDINE
2-Fluoro-5-hydroxypyridine98%
6-Fluoropyridin-3-ol | [Molecular Formula]
C5H4FNO | [MDL Number]
MFCD01075040 | [Molecular Weight]
113.09 | [MOL File]
55758-32-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
148-150°C | [Boiling point ]
319.8±22.0 °C(Predicted) | [density ]
1.325±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
9.03±0.10(Predicted) | [color ]
White to Almost white | [CAS DataBase Reference]
55758-32-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P280g-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Irritant | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
White fine crystalline powder | [Uses]
2-Fluoro-5-hydroxypyridine serves as a precursor for synthesizing 2-fluoro-5-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]pyridine and 5-(2,6-dichlorobenzyloxy)-2-fluoropyridine[3][4]. | [Synthesis]
5-Acetoxy-2-fluoropyridine (2.26 g, 14.6 mmol, from Step 8d) was used as raw material and dissolved in 20% aqueous NaOH (15 mL). The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction solution was neutralized with concentrated HCl. The aqueous phase was extracted with ethyl acetate. The organic phases were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure to remove the solvent. Purification by silica gel column chromatography (eluent: CHCl3/MeOH, 98:2) afforded 1.31 g of the target product 2-fluoro-5-hydroxypyridine in 79% yield. Mass spectra (MS) m/z: 114 (M + H)+, 131 (M + NH4)+; 1H NMR (CDCl3, 300 MHz) δ 6.84 (dd, J = 1.85,5.14 Hz, 1H), 7.43 (m, 1H), 7.81 (t, J = 2.84 Hz, 1H). | [References]
[1] Patent: US6001849, 1999, A
[2] Patent: US6133253, 2000, A |
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Energy Chemical
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Jia Xing Isenchem Co.,Ltd
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