| Identification | More | [Name]
Pseudohypericin | [CAS]
55954-61-5 | [Synonyms]
PSEUDOHYPERICIN
Phenanthro[1,10,9,8-opqra]perylene-7,14-dione,1,3,4,6,8,13-hexahydroxy-10-(hydroxymethyl)-11-methyl-
1,3,4,6,8,13-Hexahydroxy-10-(hydroxymethyl)-11-methylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
1,3,4,6,8,13-Hexahydroxy-10-hydroxymethyl-11-methylphenanthro[1,10,9,8-opqra]perylene-7,14-dione | [Molecular Formula]
C30H16O9 | [MDL Number]
MFCD00133794 | [Molecular Weight]
520.44 | [MOL File]
55954-61-5.mol |
| Chemical Properties | Back Directory | [Boiling point ]
1089.1±65.0 °C(Predicted) | [density ]
1.994±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
powder | [pka]
7.16±0.20(Predicted) | [color ]
brown | [InChIKey]
YXBUQQDFTYOHQI-UHFFFAOYSA-N | [SMILES]
Cc1cc(O)c2C(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6C(=O)c7c(O)cc(CO)c8c1c2c(c34)c(c56)c78 | [CAS DataBase Reference]
55954-61-5(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
Pseudohypericin is a specific inhibitor of protein kinase C and D-β-Hydroxylase. Also, it is used in determination of potential drug candidate molecules of Hypericum perforatum for COVID-19 treatment. | [Definition]
ChEBI: Pseudohypericin is an ortho- and peri-fused polycyclic arene. | [Biological Activity]
One of the major bioactive constituents of St. Johnμs wort (Hypericum perforatum). Implicated in the antidepressant efficacy of St. Johnμs wort. | [Synthesis]
Pseudohypericin will be extracted by the means of water immersion means pre-treatment of Hypericum perforatum raw materials, by alcohol extraction to extract solvent containing hypericin and pseudohypericin and other active ingredients, through the heatin | [Enzyme inhibitor]
This anti-retroviral agent (FW = 520.45 g/mol) inhibits protein kinase C with an IC50 value of 28.7 μM and dopamine b-hydroxylase with IC50 = 3 μM. Pseudohypericin is a component of St. John’s Wort (Hypericum perforatum). Target(s): dopamine b-hydroxylase; inositoltrisphosphate 3-kinase; and protein kinase C. |
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