| Identification | Back Directory | [Name]
[(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]acetic acid | [CAS]
56049-88-8 | [Synonyms]
Einecs 259-965-3
[[6,7-Dichloro-2-methyl-2-phenyl-1-oxoindan-5-yl]oxy]acetic acid
[(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]acetic acid
Acetic acid, 2-[(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]- | [EINECS(EC#)]
259-965-3 | [Molecular Formula]
C18H14Cl2O4 | [MOL File]
56049-88-8.mol | [Molecular Weight]
365.21 |
| Chemical Properties | Back Directory | [Melting point ]
167-168 °C(Solv: acetic acid (64-19-7)) | [Boiling point ]
553.6±50.0 °C(Predicted) | [density ]
1.422±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
2.80±0.10(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
Indacrinone (MK196) is an investigational diuretic which has pronounced saluretic activity in the rat and dog as well as both uricosuric and saluretic activity in the chimpanzee. | [in vivo]
As the dose increasing from 1 to 10 mg/kg, the amount excreted via the urine decreased from 20 to 11% of administered dose. The amount excretes via the feces is 2-fold higher at the lower dose. At the 10 mg/kg dose the Indacrinone (MK-196)/1 ratio is 0.8 and 5 for the urine and feces, respectively. The urinary ratio of Indacrinone/1 decrease as dose increasing from 10 mg/kg (0.5) to 20 mg/kg (0.2)[1]. | [References]
[1] A.G. ZACCHEI, et al. THE PHYSIOLOGICAL DISPOSITION |
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