| Identification | Back Directory | [Name]
Terminolic acid | [CAS]
564-13-6 | [Synonyms]
Terminolic acid
2α,6β,23-trihydroxyl oleanolic acid
2α,6β,23-trihydroxyl oleanolic acid
Olean-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2α,3β,4α,6β)- | [Molecular Formula]
C30H48O6 | [MDL Number]
MFCD32862538 | [MOL File]
564-13-6.mol | [Molecular Weight]
504.7 |
| Chemical Properties | Back Directory | [Melting point ]
332-334 °C | [Boiling point ]
638.1±55.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
4.59±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Terminolic acid is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum. Terminolic acid can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. Terminolic acid also exhibits moderate antibacterial activity[1][1]. | [storage]
Store at -20°C | [References]
[1] Gossan DPA, et, al. Antibacterial and cytotoxic triterpenoids from the roots of Combretum racemosum. Fitoterapia. 2016 Apr;110:89-95. DOI:10.1016/j.fitote.2016.03.002
[2] Legiawati L, et, al. In silico study of Centella asiatica active compounds as anti-inflammatory agent by decreasing Il-1 and Il-6 activity, promoting Il-4 activity. /J. Pharm. Sci. & Res. Vol. 10(9), 2018, 2142-2147. |
|
|