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56488-58-5

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56488-58-5 Structure

56488-58-5 Structure

Identification	Back Directory
[Name] Tizolemide
[CAS] 56488-58-5
[Synonyms] Tizolemide 2-Chloro-5-[4-hydroxy-3-methyl-2-(methylimino)-4-thiazolidinyl]benzenesulfonamide Benzenesulfonamide, 2-chloro-5-[4-hydroxy-3-methyl-2-(methylimino)-4-thiazolidinyl]-
[Molecular Formula] C11H14ClN3O3S2
[MOL File] 56488-58-5.mol
[Molecular Weight] 335.83

Chemical Properties	Back Directory
[Boiling point ] 568.9±60.0 °C(Predicted)
[density ] 1.59±0.1 g/cm3(Predicted)
[pka] 9.43±0.20(Predicted)

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[Uses] Tizolemide is a sulphonamide diuretic compound that has alkaline properties and is cleared by a tubular transport system. Tizolemide induces changes of passive transport components across the basolateral membrane of isolated frog skin[1][2].
[References] [1] Beermann B, et al. Diuretic effect and pharmacokinetics of tizolemide in subjects with normal and decreased renal function. Clin Nephrol. 1983 Mar;19(3):124-31. PMID:6839561 [2] Nagel W, et al. Tizolemide-induced changes of passive transport components across the basolateral membrane of isolated frog skin. Pflugers Arch. 1981 Sep;391(3):219-25. DOI:10.1007/BF00596174

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