| Identification | Back Directory | [Name]
(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE | [CAS]
56715-13-0 | [Synonyms]
(R)-(+)-ATENOLOL
Atenolol R-Isomer
(R)-(+)-AtenololHCl
(R)-(+)-Atenolol 99%
R(+)-ATENOLOL LESS ACTIVE ENANTIOME
(R)-2-(4-(2-hydroxy-3-(isopropylaMino)propoxy)phenyl)acetaMide
2-[4-[(2R)-2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide
2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
4-[(R)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide
2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]ethanamide
(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
4-[(2R)-2-Hydroxy-3-[(1-Methylethyl)aMino]propoxy]benzeneacetaMide
Benzeneacetamide, 4-[(2R)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-
Benzeneacetamide, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-, (R)-
(+)-2-[4-[(2R)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy] phenyl] acetamide
(R)-(+)-Atenolol,(+)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide | [Molecular Formula]
C14H22N2O3 | [MDL Number]
MFCD00074917 | [MOL File]
56715-13-0.mol | [Molecular Weight]
266.34 |
| Chemical Properties | Back Directory | [Melting point ]
148-152 °C(lit.)
| [Boiling point ]
508.0±50.0 °C(Predicted) | [density ]
1.125±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >6.0 mg/mL
| [form ]
solid
| [pka]
13.88±0.20(Predicted) | [color ]
pale yellow
| [Optical Rotation]
[α]25/D +16°, c = 1 in 1 M HCl | [InChI]
InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)/t12-/m1/s1 | [InChIKey]
METKIMKYRPQLGS-GFCCVEGCSA-N | [SMILES]
C1(CC(N)=O)=CC=C(OC[C@H](O)CNC(C)C)C=C1 |
| Hazard Information | Back Directory | [Description]
(+)-Atenolol is an enantiomer of the β1-adrenergic receptor (β1-AR) antagonist (±)-atenolol . (+)-Atenolol inhibits radioligand binding to β-ARs on sarcolemma-enriched membranes (Ki = 8.61 μM). Unlike (–)-atenolol and (±)-antenolol, (+)-atenolol has no effect on blood pressure in spontaneously hypertensive rats. | [Uses]
Antihypertensor | [Uses]
Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II). | [Uses]
less active enantiomer | [Definition]
ChEBI: The (R)-enantiomer of atenolol. | [IC 50]
β adrenergic receptor | [References]
[1] stoschitzky k, egginger g, zernig g, et al. stereoselective features of (r)- and (s)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies[j]. chirality, 1993, 5(1): 15-19. |
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