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29122-68-7

29122-68-7 Structure

29122-68-7 Structure
IdentificationMore
[Name]

Atenolol
[CAS]

29122-68-7
[Synonyms]

2-[4-(2-HYDROXY-3-ISOPROPYLAMINOPROPOXY)PHENYL]ACETAMIDE
(+/-)-4-(2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY)BENZENEACETAMIDE
4-[2'-HYDROXY-3'-(ISOPROPYLAMINO)-PROPOXY]PHENYLACETAMIDE
anselol
apo-atenolol
(+/-)-ATENOLOL
ATENOLOL
LABOTEST-BB LT00134657
noten
(RS)-4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]BENZENEACETAMIDE
(RS)-ATENOLOL
tenlol
TENORMIN
1-p-carbamoylmethylphenoxy-3-isopropylamino-2-propanol
2-(p-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)-acetamid
2-(p-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide
2-(p-(2-hydroxy-3-(isopropylamino)propoxy)phenylacetamide
4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-benzeneacetamid
4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-benzeneacetamid
atehexal
[EINECS(EC#)]

249-451-7
[Molecular Formula]

C14H22N2O3
[MDL Number]

MFCD00057645
[Molecular Weight]

266.34
[MOL File]

29122-68-7.mol
Chemical PropertiesBack Directory
[Appearance]

Crystalline Solid
[Appearance]

White or almost white powder.
[mp ]

154°C
[solubility ]

H2O: 0.3 mg/mL
[form ]

powder
[color ]

white to off-white
[Usage]

Cardioselective ?adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II)
[Merck ]

859
[CAS DataBase Reference]

29122-68-7(CAS DataBase Reference)
[NIST Chemistry Reference]

Atenolol(29122-68-7)
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
[Safety Statements ]

S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
[WGK Germany ]

2
[RTECS ]

AC3600000
[HS Code ]

29242990
[Hazardous Substances Data]

29122-68-7(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

4'-Hydroxyacetophenone
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Tenormin(29122-68-7).msds
Questions And AnswerBack Directory
[Pharmacological Affects]

Atenolol ,also known as atenolol, Aten Yue Er, tamoxifen, downhill Ling blood pressure, Tenormin, blood pressure Ling, is a long-acting cardioselective β1-adrenergic blockers, without intrinsic sympathomimetic activity or membrane stability.The atenolol,s retardation for β1 adrenaline receptors is similar with metoprolol, propranolol and nadolol , which is 1/6 times for pindolol and timolol. But, it does not inhibit the effect of the isoproterenol bronchodilator.When administered in small doses, it does not like non-selective β-adrenergic blockers as aggravated hypoglycemia induced hypertensive crisis, peripheral circulatory impairment or patients with obstructive airways disease worsening airway function and so on. However, When administered in large doses, atenolol also can decrease asthma or chronic obstructive pulmonary disease, airway function. Atenolol, as a long-term treatment of hypertension, also were reported for affecting airway function. Thus, despite atenolol heart selection, chronic obstructive pulmonary disease patients can only use small doses, but also should be given a sufficient amount of β1-adrenergic receptor agonists.
Oral F is 46%~60%, Tmax about 2~4 h, Mainly unchanged since the urine excretion, T1/2 of 6~7 h. Hemodialysis can clear the goods. Rapidly absorbed from the gastrointestinal tract, but not exclusively.The rest of the body is excreted in the stool. Food can reduce the F, fasting and after meals AUC decreased by 20%. Distribution of the central nervous system is relatively few. The ratio of brain tissue to blood concentration was 0.1:1. Easy to achieve in the placenta and the maternal plasma concentrations of same. PPB is less than 5%, Vd is 50~75 L. Atenolol is not metabolized by the liver, most of the drug is excreted from the body in urine, renal insufficiency in patients with T1/2 was significantly prolonged. Patients with renal failure range of T1/2 was 10~28 h, or even up to 100 h. Results at 24 h after, the discharge from the urine of the drug can be reduced by 29%. The T1/2 of patients with hyperthyroidism was significantly shortened, 4.2h.
The above information is edited by the chemicalbook of Kui Ming.
[Chemical Property]

White powder. Melting point (146-148 ℃). Soluble in alcohol, slightly soluble in water, chloroform, Hardly soluble in ethyl ether, slightly smelly.
[Uses]

β-blockers. Clinical application in the treatment of hypertension, angina and arrhythmia.
Spectrum DetailBack Directory
[Spectrum Detail]

Atenolol(29122-68-7) 13C NMR
Atenolol(29122-68-7) MS
Atenolol(29122-68-7) IR1
Atenolol(29122-68-7) 1H NMR
Atenolol(29122-68-7) IR2
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

29122-68-7(sigmaaldrich)
[TCI AMERICA]

Atenolol,>98.0%(T)(29122-68-7)
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