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56932-43-5

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56932-43-5 Structure

56932-43-5 Structure
IdentificationBack Directory
[Name]

8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT
[CAS]

56932-43-5
[Synonyms]

NAPHTHYLAZOXINE S
NAPHTHYLAZOXINE 6S
nsc-87877 disodium salt
NAPHTHYLAZOXINE S DISODIUM SALT
7-(6-Sulfo-2-naphthylazo)-8-hydroxyquinoline-5-sulfonicacid,disodiumsalt
8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-5-quinolinesulfonicacidisodium
7-(6-SULFO-2-NAPHTHYLAZO)-8-HYDROXYQUINOLINE-5-SULFONIC ACID SODIUM SALT
disodium 8-hydroxy-7-[(6-sulphonato-2-naphthyl)azo]quinoline-5-sulphonate
8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT
8-Hydroxy-7-[(6-sulfo-2-naphthalenyl)-azo]-5-quinolinesulfonic acid disodiu
8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-5-quinolinesulfonic acid disodium
8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt,98%
8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5- QUINOLINESULFONIC ACID DISODIUM SALT 98%
5-Quinolinesulfonicacid,8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-,disodiumsalt
8-Hydroxy-7-(6-sodiooxysulfonyl-2-naphtylazo)quinoline-5-sulfonic acid sodium salt
[EINECS(EC#)]

260-449-5
[Molecular Formula]

C19H11N3Na2O7S2
[MDL Number]

MFCD00041863
[MOL File]

56932-43-5.mol
[Molecular Weight]

503.42
Chemical PropertiesBack Directory
[Appearance]

dark red to red-brown powder
[storage temp. ]

Inert atmosphere,Room Temperature
[solubility ]

water: 10 mg/mL
[form ]

Solid
[color ]

Brown to black
[Water Solubility ]

water: 10mg/mL
[InChIKey]

YOGRUDWAJPVHEL-LLDDCTHSSA-L
[SMILES]

[Na+].[Na+].[S](=O)(=O)([O-])c1cc2c(cc(cc2)N\N=C3/C=C(c4c(nccc4)C/3=O)[S](=O)(=O)[O-])cc1
[EPA Substance Registry System]

5-Quinolinesulfonic acid, 8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-, disodium salt (56932-43-5)
Hazard InformationBack Directory
[Chemical Properties]

dark red to red-brown powder
[Uses]

NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].
[Biological Activity]

Cell permeable: yes''Primary Target
SHP1/2 PTPase''Product does not compete with ATP.''Reversible: no''Target IC50: 355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatasesrespectively
[in vivo]

NSC-87877 (30?mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity[3].

Animal Model:Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice[3].
Dosage:30?mg/kg.
Administration:IP once daily for 15 days.
Result:Significantly inhibited NB tumor growth.
[References]

[1] Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70. DOI:10.1124/mol.106.025536
[2] Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5. DOI:10.1016/j.bbrc.2009.02.069
[3] Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841. DOI:10.1038/cddis.2015.207
Safety DataBack Directory
[Safety Statements ]

24/25
[WGK Germany ]

WGK 2
[TSCA ]

TSCA listed
[Storage Class]

11 - Combustible Solids
Spectrum DetailBack Directory
[Spectrum Detail]

8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT(56932-43-5)1HNMR
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