| Identification | Back Directory | [Name]
SID 487795 | [CAS]
203115-63-3 | [Synonyms]
NSC 617145
NSC-617145
SID 487795
WRN inhibitor
(2,3-Propandiyl-bis(2,3-dichloro)maleimide
NSC617145;NSC-617145;NSC 617145;WRN INHIBITOR
1,1′-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-Pyrrole-2,5-dione
1,1'-(2,2-Dimethylpropane-1,3-diyl)bis(3,4-dichloro-1H-pyrrole-2,5-dione)
1H-Pyrrole-2,5-dione, 1,1'-(2,2-dimethyl-1,3-propanediyl)bis[3,4-dichloro- (9CI) | [Molecular Formula]
C13H10Cl4N2O4 | [MOL File]
203115-63-3.mol | [Molecular Weight]
400.04 |
| Chemical Properties | Back Directory | [Boiling point ]
451.5±45.0 °C(Predicted) | [density ]
1.67±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble3mg/mL, clear (warmed) | [form ]
powder | [pka]
-6.03±0.60(Predicted) | [color ]
white to light brown | [InChI]
1S/C13H10Cl4N2O4/c1-13(2,3-18-9(20)5(14)6(15)10(18)21)4-19-11(22)7(16)8(17)12(19)23/h3-4H2,1-2H3 | [InChIKey]
PCOXPBOKDABARQ-UHFFFAOYSA-N | [SMILES]
ClC1=C(C(=O)N(C1=O)CC(CN2C(=O)C(=C(C2=O)Cl)Cl)(C)C)Cl |
| Hazard Information | Back Directory | [Uses]
NSC 617145 is ahelicase inhibitor used in the treatment of Werner syndrome helicase and acts synergistically with Mitomycin C (M371900), an antitumor antibiotic. It is used as antineoplastic. | [Biological Activity]
NSC 617145 has an IC50 value of 230nM.''NSC 617145 is a potent and cell-permeable inhibitor of Werner syndrome helicase (WRN) th at causes accumulation of double-strand breaks (DSB) and chromosomal abnormalities in cancer cells. | [storage]
Store at -20°C |
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