| Identification | More | [Name]
4,5-Imidazoledicarboxylic acid | [CAS]
570-22-9 | [Synonyms]
1H-IMIDAZOLE-4,5-DICARBOXYLIC ACID
4,5-IMIDAZOLEDICARBOXYLIC ACID
AKOS AUF2071
AKOS BBS-00002898
IFLAB-BB F1918-0019
IMIDAZOLE-4,5-DICARBOXYLIC ACID
RARECHEM AL BO 1102
,-Imidazoledicarboxylicacid
4,5-Dicarboxyimidazole
4,5-Imidazoledicarboxylate
alpha,beta-Imidazoledicarboxylic acid
alpha-beta-imidazolecarboxylicacid
Glycoxalinedicarboxylic acid
glycoxalinedicarboxylicacid
Glyoxalinedicarboxylic acid
H-Imidazole-4,5-dicarboxylicacid
4,5-Imidazoledicarboxylic acid, 99℉
4,5-Imidazoledicarboxylicacid,97%
1H-Imidazole-4,5-dicarboxylic
4,5-Imidazoledicarboxylic acid, HPLC 99% | [EINECS(EC#)]
209-327-5 | [Molecular Formula]
C5H4N2O4 | [MDL Number]
MFCD00005200 | [Molecular Weight]
156.1 | [MOL File]
570-22-9.mol |
| Chemical Properties | Back Directory | [Appearance]
light yellow to yellow-brown fine cryst. powder | [Melting point ]
280-285 °C (dec.) (lit.) | [Boiling point ]
280.29°C (rough estimate) | [bulk density]
650-660kg/m3 | [density ]
1,749 g/cm3 | [refractive index ]
1.4800 (estimate) | [storage temp. ]
Store below +30°C. | [solubility ]
0.5g/l | [form ]
Fine Crystalline Powder | [pka]
3.59±0.10(Predicted) | [color ]
Light yellow to yellow-brown | [PH]
3.7 (0.5g/l, H2O, 20℃) | [Water Solubility ]
0.5g/L(20 ºC) | [BRN ]
147774 | [InChIKey]
ZEVWQFWTGHFIDH-UHFFFAOYSA-N | [CAS DataBase Reference]
570-22-9(CAS DataBase Reference) | [NIST Chemistry Reference]
4,5-Imidazole dicarboxylic acid(570-22-9) | [EPA Substance Registry System]
570-22-9(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
light yellow to yellow-brown fine cryst. powder | [Uses]
4,5-Imidazoledicarboxylic acid is an imidazole used for research purposes.
| [Uses]
4,5-Imidazoledicarboxylic Acid is an intermediate used in the synthesis of N-substituted cyclic imides with anticancer and anti-inflammatory activities. it is also used to prepare imidazolecarboxamide derivatives with cannabinoid CB2 receptor antagonistic activities. | [Synthesis]
General procedure: 800 ml of concentrated sulfuric acid (80% concentration) was slowly added to 200 ml of water to form a reaction system. To this system was added 50.0 g of 2-propylbenzimidazole, followed by the slow dropwise addition of 30 mL of hydrogen peroxide to 500 mL of the reaction mixture. The reaction is exothermic and causes reflux, and the rate of titration needs to be controlled to maintain the reaction solution at a boil. After completion of the reaction, stirring was continued for 3 hours. Subsequently, 1000 mL of water was added to the reaction mixture and cooled to room temperature. The mixture was stirred for 3 hours at 0 to 5°C to promote precipitation of solids. The solid was collected by filtration and washed sequentially with water and 5% aqueous sodium sulfite solution (100 mL). The resulting solid was purified by column chromatography using water: methanol = 2:1 as eluent to give the final imidazole-4,5-dicarboxylic acid 3-lg with a melting point of 267.3 °C (simultaneous decomposition). | [References]
[1] Patent: CN104262260, 2016, B. Location in patent: Paragraph 0093-0095 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|