| Identification | Back Directory | [Name]
(1,3-DIMETHYL-1H-PYRAZOL-5-YL)METHANOL | [CAS]
57012-20-1 | [Synonyms]
AKOS PAO-0016
BUTTPARK 93\11-63
RARECHEM AL BD 1315
(2,5-dimethyl-3-pyrazolyl)methanol
(2,5-Dimethylpyrazol-3-yl)methanol
3-diMethyl-1H-pyrazol-5-yl)Methanol
1,3-Dimethyl-1H-pyrazole-5-methanol
1H-Pyrazole-5-methanol, 1,3-dimethyl-
5-(Hydroxymethyl)-1,3-dimethylpyrazole
(2,5-Dimethyl-2H-pyrazol-3-yl)methanol
(1,3-DIMETHYL-1H-PYRAZOL-5-YL)METHANOL
1,3-DIMETHYL-5-(HYDROXYMETHYL)PYRAZOLE
(1,3-diMethyl-1h-pyrazole-5-yl)Methanol
5-(Hydroxymethyl)-1,3-dimethyl-1H-pyrazole
1,3-Dimethyl-5-(hydroxymethyl)-1H-pyrazole
(1,3-Dimethyl-1H-pyrazol-5-yl)methanol ,97% | [Molecular Formula]
C6H10N2O | [MDL Number]
MFCD02682037 | [MOL File]
57012-20-1.mol | [Molecular Weight]
126.16 |
| Chemical Properties | Back Directory | [Boiling point ]
117-118°C 0,8mm | [density ]
1.13±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
14.37±0.10(Predicted) | [Appearance]
Light yellow to yellow Solid |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow solid | [Synthesis]
Step 1: Preparation of (2,5-dimethyl-2H-pyrazol-3-yl) methanol (14): to a solution of compound 13 (4.5 g, 24.7 mmol) in THF (60 mL) was added lithium aluminum hydride (LiAlH4) (1.22 g, 32.1 mmol) in batches at 0°C under nitrogen atmosphere. The reaction mixture was stirred at the same temperature for 2-3 h. The excess LiAlH4 was subsequently quenched by addition of saturated sodium sulfate solution.The reaction mixture was filtered and the residue was washed with ethyl acetate. The filtrates were combined and concentrated under reduced pressure to afford the target product (2,5-dimethyl-2H-pyrazol-3-yl) methanol (14) 3 g as a brown solid. Yield: 86%; 1H NMR (200 MHz, CDCl3): δ 6.0 (s, 1H), 4.57 (d, J = 5.9 Hz, 2H), 3.8 (s, 3H), 3.16 (s, 1H), 2.24 (s, 3H); Mass Spectrometry (CI method, isobutane): 127 (M+1, 100%); IR (KBr, cm-1 ): ν max 3281. | [References]
[1] Patent: US2006/128729, 2006, A1. Location in patent: Page/Page column 98 |
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