| Identification | Back Directory | [Name]
4-(4-Morpholinobutylthio)phenol | [CAS]
57055-82-0 | [Synonyms]
MoTP
33N14
4-(4-Morpholinobutylthio)phenol
4-(4-morpholin-4-ylbutylsulfanyl)phenol
Phenol, 4-[[4-(4-morpholinyl)butyl]thio]- | [Molecular Formula]
C14H21NO2S | [MDL Number]
MFCD00642470 | [MOL File]
57055-82-0.mol | [Molecular Weight]
267.39 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO: ≥80mg/mL | [form ]
powder | [color ]
white to tan | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. | [InChI]
1S/C14H21NO2S/c16-13-3-5-14(6-4-13)18-12-2-1-7-15-8-10-17-11-9-15/h3-6,16H,1-2,7-12H2 | [InChIKey]
YHKNLUTUXZDOQI-UHFFFAOYSA-N | [SMILES]
Oc1ccc(SCCCCN2CCOCC2)cc1 |
| Hazard Information | Back Directory | [Description]
MoTP (57055-82-0) specifically ablates zebrafish larval melanocytes. Melanocytotoxicity is dependent on tyrosinase activity.1,2 MoTP is a useful tool for elucidating melanocyte stem cell regeneration, recruitment and maintenance.3-5 | [Uses]
MoTP is a specific platelet activating factor receptor antagonist and can induce melanocyte ablation. MoTP can be used for the research of cancer. | [References]
1) Yang et al. (2006), Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes; Development, 133 3563
2) Yang et al. (2007), Mutations in gfpt1 and skiv2I2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish; PLoS Genet., 3 e88
3) Hultman et al. (2009), Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes; PLoS Genet., 5 e1000544
4) Hultman et al. (2010), Differential contribution of direct-developing and stem cell-derived melanocytes to the zebrafish larval pigment pattern; Dev. Biol., 337 425
5) Hultman et al. (2008), Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytes; Zebrafish, 5 279 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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