| Identification | More | [Name]
(R)-(-)-3-Chloro-1,2-propanediol | [CAS]
57090-45-6 | [Synonyms]
(2R)-3-CHLOROPROPANE-1,2-DIOL
GLYCEROL (R)-(-)-ALPHA-MONOCHLOROHYDRIN
(R)-(-)-3-CHLORO-1,2-PROPANEDIOL
(R)-3-CHLORO-1,2-PROPANEDIOL
(R)-3-CHLOROPROPANE-1,2-DIOL
(R)-(-)-3-GLYCEROL ALPHA-MONOCHLOROHYDRIN
(R)-(-)-ALPHA-CHLOROHYDRIN
(R)-ALPHA-GLYCEROL CHLOROHYDRIN
(R)-(-)-ALPHA-MONOCHLOROHYDRIN
(R)-GLYCEROL ALPHA-MONOCHLOROHYDRIN
(R)-(−
)-3-Chloro-1,2-propanediol
(R)-α-Glycerol chlorohydrin
Chloropropanediol,98%
(R)/(S)-3-Chloro-1,2-Propanediol
R-Chloropropanediol
(R)-(-)-3-CHLORO-1,2-PROPANEDIOL , EE 98%
R-3-CHLOROPROPANE DIOL
(R)-3-CHLORO-1,2-PROPANEDIOL ,98%MIN
(R)-(-)-3-Chloro-1,2-propanediol, 97%, ee 98%
(-)-α-monochlorohydrine | [EINECS(EC#)]
435-560-9 | [Molecular Formula]
C3H7ClO2 | [MDL Number]
MFCD00135169 | [Molecular Weight]
110.54 | [MOL File]
57090-45-6.mol |
| Chemical Properties | Back Directory | [Appearance]
clear light yellow liquid | [Melting point ]
-40°C | [alpha ]
-0.9 º (neat) | [Boiling point ]
213 °C(lit.)
| [density ]
1.321 g/mL at 20 °C(lit.)
| [vapor pressure ]
0.04 mm Hg ( 25 °C)
| [refractive index ]
n20/D 1.48(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
soluble in Chloroform, Methanol | [form ]
clear liquid | [pka]
13.28±0.20(Predicted) | [color ]
Colorless to Brown | [Specific Gravity]
1.322 | [Optical Rotation]
[α]20/D 1°, neat | [Water Solubility ]
soluble | [BRN ]
2202928 | [InChIKey]
SSZWWUDQMAHNAQ-VKHMYHEASA-N | [LogP]
0.5 at 25℃ | [CAS DataBase Reference]
57090-45-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R25:Toxic if swallowed.
R41:Risk of serious damage to eyes.
R68:Possible risk of irreversible effects.
R62:Possible risk of impaired fertility.
R36/37/38:Irritating to eyes, respiratory system and skin .
R23/25:Toxic by inhalation and if swallowed .
R21:Harmful in contact with skin. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S39:Wear eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 2689 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
TY4025000 | [F ]
3 | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29053200 |
| Hazard Information | Back Directory | [Chemical Properties]
clear light yellow liquid | [Uses]
(R)-(-)-3-Chloro-1,2-propanediol is used as a reagent in the synthesis of PA-824, which is a promising antituberculosis drug candidate that has been synthesized. It is also used in the manufacture of L-carnitine, which is a quaternary ammonium compound involved in metabolism in most mammals, plants, and some bacteria.
| [Definition]
ChEBI: The (R)-stereoisomer of 3-chloro-1,2-propanediol. | [Health Hazard]
The toxicological evaluation revealed that (R)-(-)-3-Chloro-1,2-propanediol was genotoxic in humans and had anti-fertility effects in male rats. The discharge of this compound into wastewater might cause serious environmental hazards[1]. | [References]
[1] Yun‐Xu Yang. “Practical and Efficient Utilisation of (R)-3-chloro-1,2-Propanediol in Synthesis of L-Carnitine.” Journal of Chemical Research-s 93 1 (2011): 371–372.
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