| Identification | Back Directory | [Name]
5,7,4'-trihydroxy-8-methoxyflavone | [CAS]
57096-02-3 | [Synonyms]
-Hydroxywogonin
4'-Hydroxywogonin
5,7,4'-trihydroxy-8-methoxyflavone
5,7-dihydroxy-2-(4-hydroxyphenyl)-8-methoxychromen-4-one
4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-methoxy- | [EINECS(EC#)]
2017-001-1 | [Molecular Formula]
C16H12O6 | [MDL Number]
MFCD00936847 | [MOL File]
57096-02-3.mol | [Molecular Weight]
300.26 |
| Chemical Properties | Back Directory | [Melting point ]
303-305 °C(Solv: chloroform (67-66-3); methanol (67-56-1)) | [Boiling point ]
578.1±50.0 °C(Predicted) | [density ]
1.512±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
6.84±0.40(Predicted) | [color ]
Yellow | [InChI]
InChI=1S/C16H12O6/c1-21-15-12(20)6-10(18)14-11(19)7-13(22-16(14)15)8-2-4-9(17)5-3-8/h2-7,17-18,20H,1H3 | [InChIKey]
OEZZJTAJYYSQKM-UHFFFAOYSA-N | [SMILES]
C1(C2=CC=C(O)C=C2)OC2=C(OC)C(O)=CC(O)=C2C(=O)C=1 |
| Hazard Information | Back Directory | [Uses]
4''-Hydroxywogonin can be used as an antiviral drug screening for COVID-19 therapy. | [in vivo]
4′-Hydroxywogonin (10 and 20 mg/kg; i.p.; male C57BL/6 mice) alleviates LPS-induced acute lung injury (ALI) in a mouse model[1]. | Animal Model: | Male C57BL/6 mice (6-8 weeks old; 20 g) with acute lung injury model[1] | | Dosage: | 10 and 20 mg/kg | | Administration: | Intraperitoneal injection, 12 and 1 h before LPS treatment | | Result: | Had potential protective effects against inflammation in LPS induced ALI mice.
Attenuated the degree of leukocyte infiltration.
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