| Identification | Back Directory | [Name]
NAFTOPIDIL DIHYDROCHLORIDE | [CAS]
57149-08-3 | [Synonyms]
KT-611 2HCl
Naftopidil HCL
NAFTOPIDIL 2HCL
piperazin-1-yl)
Naftopidil DiHCl
1-(4-(2-Methoxyphenyl)
KT-611 DIHYDROCHLORIDE
-3-(naphthalen-1-yloxy)
propan-2-ol dihydrochloride
NAFTOPIDIL DIHYDROCHLORIDE USP/EP/BP
3-[(4-methylpiperazin-1-yl)methyl]quinazolin-4-one dihydrochloride
4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol,2HCl
1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphthoxy)-2-propanol dihydrochloride
4-(2-METHOXYPHENYL)-A-[(1-NAPHTHALENYLOXY)METHYL]-1-PIPERAZINEETHANOL, DIHYDROCHLORIDE
1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(naphthalen-1-yloxy)propan-2-ol dihydrochloride
4-(2-METHOXYPHENYL)-ALPHA-([1-NAPHTHALENYLYOXY]METHYL)-1-PIPERAZINEETHANOL DIHYDROCHLORIDE | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C24H30Cl2N2O3 | [MDL Number]
MFCD00153845 | [MOL File]
57149-08-3.mol | [Molecular Weight]
465.41 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
A α-1-Adrenergic receptor antagonist, antihypertensive. | [Uses]
Antihypertensive;Alpha1 agonist | [in vivo]
Naftopidil dihydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model[2].
| Animal Model: | Male athymic mice(7-8 weeks), with E9+PrSC xenograft[2] | | Dosage: | 10 mg/kg | | Administration: | Oral administration, daily, for 28 days | | Result: | Decreased tumor weights. |
| [IC 50]
Alpha-1A adrenergic receptor: 3.7 nM (Ki); Alpha-1B adrenergic receptor: 20 nM (Ki); Alpha-1D adrenergic receptor: 1.2 (Ki) |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Telephone: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0_EN.htm |
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