| Identification | More | [Name]
4-Biphenylacetic acid | [CAS]
5728-52-9 | [Synonyms]
[1,1'-BIPHENYL]-4-ACETIC ACID
4-BIPHENYLACETIC ACID
4-CARBOXYMETHYLBIPHENYL
4-PHENYLPHENYLACETIC ACID
BIPHENYL-4-ACETIC ACID
CI 83544
FELBINAC
P-BIPHENYLACETIC ACID
RARECHEM AL BO 0343
4-Diphenylacetic Acid
Felbinac(4-BiphenylaceticAcid)
4-Biphenylaceticacid,98+%
4-BIPHENYLYLACETIC ACID
P-BIPHENYLYLACETIC ACID
4-BIPHENYLACETICABID
Biphenyl-4-acetic acid 97%
4-Biphenylacetic acid/Felbinac
4-BIPHENYLACETIC ACID 99% BP GRADE
4-BIPHENYL ACETIC ACID 98.5%
4-BIPHENYLACETIC ACID(METHOXYMETHYL)-1,1''-BIPHENYL | [EINECS(EC#)]
227-233-2 | [Molecular Formula]
C14H12O2 | [MDL Number]
MFCD00004351 | [Molecular Weight]
212.24 | [MOL File]
5728-52-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-white powder | [Melting point ]
159-160 °C (lit.) | [Boiling point ]
312.08°C (rough estimate) | [density ]
1.1035 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble50mg/mL, clear, colorless to yellow | [form ]
Powder | [pka]
4.29±0.10(Predicted) | [color ]
Beige | [Water Solubility ]
39.27mg/L(25 ºC) | [Detection Methods]
T,NMR | [Merck ]
14,3951 | [BRN ]
1211592 | [InChI]
InChI=1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16) | [InChIKey]
QRZAKQDHEVVFRX-UHFFFAOYSA-N | [SMILES]
C1(C2=CC=CC=C2)=CC=C(CC(O)=O)C=C1 | [CAS DataBase Reference]
5728-52-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xn | [Risk Statements ]
R23/25:Toxic by inhalation and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R25:Toxic if swallowed.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S37/39:Wear suitable gloves and eye/face protection .
S20:When using, do not eat or drink .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
DU8229050
| [Hazard Note ]
Irritant | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29163900 | [Toxicity]
LD50 orally in rats: 164 mg/kg (Sloboda, Osterberg) |
| Hazard Information | Back Directory | [Description]
Felbinac Is the active metabolite of the non-steroidal antiinflammatory agent,
fenbufen. Applied topically as a gel to joints, it is useful in the symptomatic relief
of articular inflammation and pain. | [Chemical Properties]
Off-white powder | [Originator]
Lederle (USA) | [Uses]
4-Biphenylacetic acid was used in the synthesis of gastrosparing non-steroidal antiinflammatory drug. | [Uses]
Anti-inflammatory, analgesic drug. | [Definition]
ChEBI:Biphenyl-4-ylacetic acid is a monocarboxylic acid in which one of the alpha-hydrogens is substituted by a biphenyl-4-yl group. An active metabolite of fenbufen, it is used as a topical medicine to treat muscle inflammation and arthritis. It has a role as a non-steroidal anti-inflammatory drug. It is a member of biphenyls and a monocarboxylic acid. It contains a biphenyl-4-yl group. It is functionally related to an acetic acid. | [Brand name]
Dolinac (Wyeth-Ayerst); Flexfree(Wyeth-Ayerst); Napageln (Wyeth-Ayerst); Target
(Wyeth-Ayerst); Traxam (Wyeth-Ayerst). | [General Description]
4-Biphenylacetic acid is a potential non-steroidal antiinflammatory agent and forms solid inclusion complex with β-cyclodextrin. 4-Biphenylacetic acid on interaction with quinolone antibacterial agents induces functional blockade of the γ-aminobutyric acid receptors. | [Safety Profile]
Poison by subcutaneous route.Moderately toxic by ingestion and intraperitoneal routes.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits acrid smoke and fumes. | [Synthesis]
First 4-aminophenylacetic acid is prepared by reducing 4-nitrophenylacetic acid in the presence of a palladium-carbon catalyst; 4-Biphenylacetic acid is finally prepared by reacting 4-aminophenylacetic acid with benzene in the presence of sodium nitrite and an acid.
| [storage]
Store at -20°C |
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