| Identification | Back Directory | [Name]
Talinolol | [CAS]
57460-41-0 | [Synonyms]
Cordanum
rac-Talinolol
Racemic talinolol
1-(4-(Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol
1-(4-Cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane
1-(4-(3-(tert-butylaMino)-2-hydroxypropoxy)phenyl)-3-cyclohexylu
1-(3-(3-Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol
1-(2-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea
1-(4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea
(+-)-1-(p-(3-(tert-Butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea
( -)-1-(4-(3-(tert-Butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylharnstoff | [Molecular Formula]
C20H33N3O3 | [MDL Number]
MFCD00864592 | [MOL File]
57460-41-0.mol | [Molecular Weight]
363.49 |
| Chemical Properties | Back Directory | [Melting point ]
160-162°C | [Boiling point ]
520.0±50.0 °C(Predicted) | [density ]
1.11±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
13.82±0.20(Predicted) | [color ]
White to Pale Pink | [InChI]
InChI=1S/C20H33N3O3/c1-20(2,3)21-13-17(24)14-26-18-11-9-16(10-12-18)23-19(25)22-15-7-5-4-6-8-15/h9-12,15,17,21,24H,4-8,13-14H2,1-3H3,(H2,22,23,25) | [InChIKey]
MXFWWQICDIZSOA-UHFFFAOYSA-N | [SMILES]
N(C1CCCCC1)C(NC1=CC=C(OCC(O)CNC(C)(C)C)C=C1)=O |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [HazardClass ]
IRRITANT | [Storage Class]
11 - Combustible Solids | [Toxicity]
LD50 in rats, mice (mg/kg): 1180, 593 orally; 54.3, 74.7 i.p.; 29.7, 25.0 i.v. (Femmer) |
| Hazard Information | Back Directory | [Description]
(±)-Talinolol is a β1-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.1 By blocking β1-adrenergic receptors, talinolol delays the conduction of stimuli in the AV node, reduces the sino-atrial conduction time, and impedes the sinus node automaticity.1 Because its metabolism in human liver microsomes is well understood, (±)-talinolol is useful for examining the activity of the drug-transporting MDR1 gene product P-glycoprotein.2,3,4 | [Chemical Properties]
Off-White to Pale Pink Solid | [Uses]
Selective β1-adrenergic blocker structurally related to Practolol. Antihypertensive; antiarrhythmic. | [Definition]
ChEBI: Talinolol is a member of ureas. | [in vivo]
Talinolol (20 mg/kg; i.p.) plasma and liver AUC0-5 h are increased by Zosuquidar administration[2].
Bioavailability of Talinolol can be enhanced by coadministration with grapefruit juice (GFJ) in rats[3]. | [IC 50]
Beta-1 adrenergic receptor | [References]
[1] abmann i. the actions of talinolol, a β1-selective beta blocker, in cardiac arrhythmia and acute myocardial infarction[j]. current medical research and opinion, 2008, 13(6): 325-342.
[2] trausch b, oertel r, richter k, et al. disposition and bioavailability of the β1‐adrenoceptor antagonist talinolol in man[j]. biopharmaceutics & drug disposition, 1995, 16(5): 403-414. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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