| Identification | Back Directory | [Name]
R 112 (pharMaceutical) | [CAS]
575474-82-7 | [Synonyms]
R112, >98%
R-112; R 112
(E)-Elafibranor
R 112 (pharMaceutical)
3,3'-[(5-Fluoro-2,4-pyrimidinediyl)diimino]diphenol
Phenol, 3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis- | [Molecular Formula]
C16H13FN4O2 | [MOL File]
575474-82-7.mol | [Molecular Weight]
312.3 |
| Chemical Properties | Back Directory | [Boiling point ]
552.0±60.0 °C(Predicted) | [density ]
1.494±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:30.0(Max Conc. mg/mL);96.1(Max Conc. mM) | [form ]
A crystalline solid | [pka]
9.48±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
R112 is an inhibitor of spleen tyrosine kinase (Syk; IC50 = 226 nM in cultured human mast cells) that acts in an ATP-competitive and reversible manner (Ki = 96 nM). It inhibits mast cell and basophil degranulation induced by anti-IgE cross-linking (EC50s = 353 and 280 nM, respectively). It also inhibits basophil degranulation induced by an allergen with an EC50 value of 490 nM. R112 inhibits the production of leukotriene C4 (LTC4; ) and decreases cytokine levels in cultured human mast cells. | [Uses]
R 112 is Syk inhibitor. It can be used in biological study and therapeutic use of application of cultured human mast cells (CHMC) for design and structure-activity relationship of IgE-mediated mast cell activation inhibitors. | [storage]
Store at -20°C | [References]
[1] ALEXANDER B. ROSSI BA. Identification of the Syk kinase inhibitor R112 by a human mast cell screen[J]. Journal of Allergy and Clinical Immunology, 2006, 118 3: Pages 749-755. DOI: 10.1016/j.jaci.2006.05.023 |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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