| Identification | Back Directory | [Name]
Syk Inhibitor II | [CAS]
227449-73-2 | [Synonyms]
Syk Inhibitor II
Syk Inhibitor II (hydrochloride)
2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamide Hydrochloride | [Molecular Formula]
C14H16ClF3N6O | [MOL File]
227449-73-2.mol | [Molecular Weight]
376.77 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 2 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.3 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
A crystalline solid | [color ]
off-white | [InChI]
1S/C14H15F3N6O.2ClH.2H2O/c15-14(16,17)8-2-1-3-9(6-8)22-12-10(11(19)24)7-21-13(23-12)20-5-4-18;;;;/h1-3,6-7H,4-5,18H2,(H2,19,24)(H2,20,21,22,23);2*1H;2*1H2 | [InChIKey]
LCACSMNPIITJGG-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Uses]
2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamide Hydrochloride was identified via a small molecule screening assay. In addition, this compound inhibits tyrosine kinase and may be a useful reagent to investigate cellular signalling pathways. | [Biological Activity]
Cell permeable: yes''Primary Target
Syk''Product competes with ATP.''Reversible: yes''Target IC50: 41 nM against Syk; 460 nM against FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro | [in vivo]
Syk Inhibitor II (Compound 9a; 10-100 mg/kg) dihydrochloride is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg[1]. | Animal Model: | ICR mice[1] | | Dosage: | 10, 30, 100 mg/kg | | Administration: | S.c.; 30 min before antigen challenge | | Result: | Inhibited the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg. |
| [IC 50]
5-HT Receptor: 460 nM (IC50) | [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|