| Identification | Back Directory | [Name]
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid | [CAS]
57719-81-0 | [Synonyms]
Pteris diterpenoid 5F
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
Kaur-16-en-18-oic acid, 11-hydroxy-15-oxo-, (4α,11β)-
(4alpha,11beta)-11-Hydroxy-15-oxokaur-16-en-18-oic acid | [Molecular Formula]
C20H28O4 | [MDL Number]
MFCD28100348 | [MOL File]
57719-81-0.mol | [Molecular Weight]
332.44 |
| Hazard Information | Back Directory | [Uses]
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis tyrosinase inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds[1]. | [References]
[1] Kuroi A, et al. The Importance of 11-OH, 15-oxo, and 16-en Moieties of 11-Hydroxy-15-oxo-kaur-16-en-19-oic Acid in Its Inhibitory Activity on Melanogenesis. Skin Pharmacol Physiol. 2017;30(4):205-215. DOI:10.1159/000475471 |
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