| Identification | More | [Name]
4-Aminoguinoline | [CAS]
578-68-7 | [Synonyms]
4-AMINOQUINOLINE
4-QUINOLINAMINE
4-Quinolylamine
QUINOLIN-4-YLAMINE
4-Aminoguinoline
Quinolin-4-amine | [EINECS(EC#)]
640-116-4 | [Molecular Formula]
C9H8N2 | [MDL Number]
MFCD00463448 | [Molecular Weight]
144.17 | [MOL File]
578-68-7.mol |
| Questions And Answer | Back Directory | [Preparation]
Research has found that, under transition metal-free conditions, a series of 4-Aminoguinoline and their derivatives can be synthesized via a three-component one-pot method using amines, benzenesulfonyl acetonitrile, and dimethyl sulfoxide as substrates through catalytic oxidation cyclization reactions. |
| Chemical Properties | Back Directory | [Melting point ]
151.0 and le 155.0 °C | [Boiling point ]
312.78°C (estimate) | [density ]
1.1148 (estimate) | [refractive index ]
1.7080 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
powder to crystalline | [pka]
9.17(at 20℃) | [color ]
White to Yellow to Orange | [Detection Methods]
HPLC | [InChI]
InChI=1S/C9H8N2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H2,10,11) | [InChIKey]
FQYRLEXKXQRZDH-UHFFFAOYSA-N | [SMILES]
N1C2C(=CC=CC=2)C(N)=CC=1 | [CAS DataBase Reference]
578-68-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P271-P261-P280 | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
2811 | [WGK Germany ]
WGK 3 | [HS Code ]
29334900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
Light brown to grey solid | [Uses]
4-Quinolinamine and its derivatives are commonly used as anti-malarial drugs and also have potential therapeutic effects on patients afflicted with arthritis (and/or related diseases). | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 43, p. 4667, 2000 DOI: 10.1021/jm0002073
Tetrahedron Letters, 39, p. 1313, 1998 DOI: 10.1016/S0040-4039(97)10877-2 | [Purification Methods]
It has been purified by zone refining and recrystallisation from *C6H6, EtOH or H2O. The hydrochloride has m 308o (from MeOH), and the picrate has m 277o (from EtOH). [Albert et al. J Chem Soc 2240 1948, Beilstein 22 III/IV 4611, 22/10 V 341.] |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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