| Identification | Back Directory | [Name]
2-AMINO-5,6-DIMETHYLPYRIDINE | [CAS]
57963-08-3 | [Synonyms]
NSC 95996
6-AMino-2,3-lutidine
5,6-diMethyl-2-PyridinaMine
5,6-dimethylpyridin-2-amine
2-amino-5,6-dimethylpyridin
5,6-Dimethyl-2-aminopyridine
6-Amino-2,3-dimethylpyridine
2-AMINO-5,6-DIMETHYLPYRIDINE
2-Pyridinamine,5,6-dimethyl-
2-Amino-5,6-dimenthylpyridine
(5,6-dimethyl-2-pyridyl)amine
5,6-DIMETHYL-PYRIDIN-2-YLAMINE
5,6-Dimethylpyridin-2-amine, 2-Amino-5,6-dimethylpyridine, 6-Amino-2,3-lutidine | [Molecular Formula]
C7H10N2 | [MDL Number]
MFCD06200777 | [MOL File]
57963-08-3.mol | [Molecular Weight]
122.17 |
| Chemical Properties | Back Directory | [Appearance]
Light Yellow Low-Melting Solid | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Chloroform, Dichloromethane | [form ]
Solid | [color ]
Light Yellow | [InChI]
InChI=1S/C7H10N2/c1-5-3-4-7(8)9-6(5)2/h3-4H,1-2H3,(H2,8,9) | [InChIKey]
UZAOIPZZPZCFES-UHFFFAOYSA-N | [SMILES]
C1(N)=NC(C)=C(C)C=C1 | [CAS DataBase Reference]
57963-08-3 |
| Hazard Information | Back Directory | [Chemical Properties]
Light Yellow Low-Melting Solid | [Synthesis]
A mixture of 2-amino-5-bromo-6-methylpyridine (561 mg, 3.0 mmol), K2CO3 (1.24 g, 9.0 mmol) and Pd(dppf)Cl2·CH2Cl2 (245 mg, 0.30 mmol) was added to a solution of trimethylboroxine (377 mg, 3.0 mmol) in water (1 mL) and dioxane (10 mL). The mixture was heated at reflux for 3 h. After cooling to rt, the mixture was poured into water (50 mL). The mixture was extracted with diethyl ether (3*50ml), and the combined organic phases were dried (Na2SO4) and concentrated. Purification by chromatography (EtOAc/heptane) gave 5,6-Dimethylpyridin-2-amine as a black-brown solid. Yield: 67 %.
| [References]
[1] Patent: WO2007/51981, 2007, A1. Location in patent: Page/Page column 61
[2] Patent: WO2007/51982, 2007, A1. Location in patent: Page/Page column 53 |
| Questions And Answer | Back Directory | [Application]
Pyridine and its derivatives are widely found in nature. The molecular structures of nicotinic acid and nicotinamide, both B vitamins, contain pyridine rings, and some alkaloids also commonly contain pyridine rings. 2-Amino-5,6-dimethylpyridine is a pyridine derivative that can be used as a pharmaceutical synthesis intermediate. |
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