ChemicalBook--->CAS DataBase List--->58-89-9

58-89-9

58-89-9 Structure

58-89-9 Structure
IdentificationBack Directory
[Name]

LINDANE
[CAS]

58-89-9
[Synonyms]

666
BBH
HGI
plk
HCH
HCCH
Kwell
Bexol
G-BHC
D-BHC
D-HCH
tap85
Viton
TRI-6
TAP 85
HCH(R)
HGI(R)
GEXANE
Gamene
gamiso
Hortex
Lintox
Linvur
Lindex
inexit
Isotox
Lentox
Lidenal
Jacutin
Hexatox
Lendine
Mszycol
nexenfb
novigam
Esoderm
Gamacid
detox25
Devoran
bhc50wp
Celanex
Ben-Hex
Aplidal
Arbitex
Aficide
Scabene
LINDANE
Acrodal
Lindene
APHTIRIA
KEWLL(R)
Streunex
silvanol
Agrocide
Aalindan
benhexol
ent7,796
bentox10
Aparasin
Gammalin
Owadziak
Quellada
Nexen FB
Pflanzol
lindane1
Lindosep
milbol49
Lorexane
mglawikl
Hexaverm
Hexicide
Hexyclan
Heclotox
Gammasan
geobilan
geoling3
Kokotine
hilbeech
gamaphex
Lindafor
lindagam
Gammaterr
Milbol 49
lasochron
sanggamma
New kotol
Pedraczak
gallogama
Codechine
Entomoxan
ENT 7,796
Bentox 10
agronexit
agrocide2
agrocide7
GAMMA-COL
GAMMA-BHC
GAMMA-HCH
GAMMEXANE
DELTA-HCH
DELTA-BHC
ISOTOX(R)
LINTOX(R)
Chloroble
BEN-HEX(R)
JUCUTIN(R)
agrocide6g
agrocidewp
Ameisentod
Chloresene
dolgranule
gamacide20
nci-c00204
Sang-gamma
hungarial7
laccohilin
gammalin20
lindagrain
lindagranox
Hexachloran
lindapoudre
forst-nexen
Gammalin 20
Dol Granule
Agrocide WP
agrocideiii
LOREXANE(R)
APARASIN(R)
STREUNEX(R)
'LGC' (1103)
'LGC' (1104)
Agrocide III
gamacarbatox
Hexachlorane
gammalindane
gamma-Lindane
gamma-mean400
fenoformforte
Atlas steward
gamma-Isomere
verindalultra
spritzlindane
Spritz-Rapidin
Spruehpflanzol
Scabene lotion
Fumite lindane
Gamma-BHC dust
Gamma-HCH dust
Detmol-Extrakt
Neo-Scabicidol
lindane (g-BHC)
Lindan solution
gamma-HCH (BHC)
Lindane (200 mg)
BHC GAMMA ISOMER
lindane,[liquid]
gamma-Hexachloran
BHC β-isomer
GaMMa-BHC solution
BHC (DELTA ISOMER)
LINDANE, 1GM, NEAT
gamma-Hexachlorane
ameisenmittelmerck
Ameisenmittel merck
rcrawastenumberu129
gamma-hch (bsi,iso)
gamma-BHC (Lindane)
gamma-bhc (jmaf,iso)
BENZENE HEXACHLORIDE
hexachlorocyolohexane
gamma-HCH or gamma-BHC
GAMMA-BHC, 1000MG, NEAT
Lindane(BHCgammaisomer)
γ-HCH, Lindane solution
gamma-Hexachlorobenzene
gamma-benzohexachloride
drilltox-spezialaglukon
Drilltox-Spezial Aglukon
Lindane 500mg [58-89-9]
DELTA-BENZENEHEXACHLORIDE
Murfume grain store smoke
GAMMA-BENZENE HEXACHLORIDE
GAMMA-HEXACHLORCYCLOHEXANE
GAMMA-HEXACHLOROCYCLOHEXANE
DELTA-HEXACHLOROCYCLOHEXANE
Benzene Hexachloride, gamma
lindane, gamma-isomer of HCH
GAMMA-BHC, 1X10ML, ISO, 2UG/ML
GAMMA-BHC, 1X1ML, MEOH, 20UG/ML
Benzene Hexachloride (γ-Isomer)
GAMMA-BHC (LINDANE), 250MG, NEAT
GAMMA-BHC, 1X1ML, MEOH, 1000UG/ML
hexachlorocyclohexanegamma-isomer
Hexachlorocyclohexane,gamma-isomer
GAMMA-BHC, 1X1ML, HEXANE, 0.1UG/ML
BENZENE HEXACHLORIDE (GAMMA-ISOMER)
g-1,2,3,4,5,6-Hexachlorocyclohexane
2,3,4,5,6-hexachloro-gamma-cyclohexan
1,2,3,4,5,6-gamma-Hexachlorocyclohexane
GAMMA-1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE
gamma-1,2,3,4,5,6-hexachorocy-clohexane
LINDANE (a.k.a. gamma-BHC or gamma-HCH)
LINDAN PESTANAL (GAMMA-HEXACHLORO- CYCLO
GAMMA-BHC (13C6, 100+/-10UG/ML IN NONANE)
Hexachlorocyclohexane, (gamma.-BHC (ISO))
1,2,3,4,5,6-Hexachlorocyclohexane (gamma)
lindane(1,2,3,4,5,6-hexachlorocyclohexane)
Lindane (BHC gamma isomer) 500mg [58-89-9]
1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE [G-ISOMER]
1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE [D-ISOMER]
Cyclohexane, 1,2,3,4,5,6-hexachloro-, gamma-
1,2,3,4,5,6-hexachloro-cyclohexangamma-isomer
r-1,c-2,t-3,c-4,c-5,t-6-hexachlorocyclohexane
1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE, GAMMA-ISOMER
γ-BHC, 1α,2α,3β,4α,5α,6β-Hexachlorocyclohexane
Cyclohexane, 1,2,3,4,5,6-hexachloro-, gamma-isomer
1,2cis,3trans,4cis,5cis,6trans-hexachloro-cyclohexane
(1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane
γ-BHC, Lindane, 1α,2α,3β,4α,5α,6β-Hexachlorocyclohexane
γ-HCH or γ-BHC γ-1,2,3,4,5,6-hexachlorocyclohexane lindane
1ALPHA,2ALPHA,3BETA,4ALPHA,5ALPHA,6BETA-HEXACHLOROCYCLOHEXANE
Benzene Hexachloride (gamma-Isomer) gamma-BHC gamma-HCH Lindane
1,2,3,4,5,6-hexachlorocyclohexane,gammaisomer(lindane,gamma-bhc)
1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE, GAMMA -ISOMER, 97% (GAMMA-BHC)
cyclohexane,1,2,3,4,5,6-hexachloro-,(1alpha,2alpha,3beta,4alpha,5alpha,6
Cyclohexane, 1,2,3,4,5,6-hexachloro-, (1alpha,2alpha,3beta,4alpha,5alpha,6beta)-
γ-1,2,3,4,5,6-Hexachlorocyclohexane, γ-benzene hexachloride, Lindane solution
1,2,3,4,5,6-hexachloro-,(1.alpha.,2.alpha.,3.beta.,4.alpha.,5.alpha.,6.beta.)-Cyclohexane
[EINECS(EC#)]

200-401-2
[Molecular Formula]

C6H6Cl6
[MDL Number]

MFCD00135947
[MOL File]

58-89-9.mol
[Molecular Weight]

290.83
Chemical PropertiesBack Directory
[Appearance]

Lindane is a white to yellow, crystalline powder with a slight, musty odor (pure material is odorless).
[Melting point ]

113-115 °C(lit.)
[Boiling point ]

373.64°C (rough estimate)
[density ]

1.7152 (rough estimate)
[vapor pressure ]

28.0, 55.3, 87.0, 168.8, 285.8, 297.0, and 538.5 at 19.58, 24.95, 28.42, 33.58, 37.82, 37.86, and43.32 °C, respectively (Boehncke et al., 1996)
[refractive index ]

nD20 1.644
[Fp ]

11 °C
[storage temp. ]

0-6°C
[solubility ]

H2O: insoluble0.01g/L (practically)
[form ]

neat
[Water Solubility ]

7.3 mg l-1 (25 °C)
[Stability:]

Stable. Incompatible with strong oxidizing agents.
[Merck ]

13,5523
[BRN ]

1907337
[Henry's Law Constant]

12.8 at 5 °C, 14.8 at 15 °C, 18.8 at 20 °C, 26.6 at 25 °C, 38.5 at 35 °C (gas stripping-GC, Cetin et al., 2006)
[Exposure limits]

NIOSH REL: TWA 0.5 mg/m3, IDLH 50 mg/m3; OSHA PEL: TWA 0.5 mg/m3; ACGIH TLV: TWA 0.5 mg/m3.
[Contact allergens]

Lindane is a pesticide used for its antiinsect properties in agriculture, wood protection, in antiinsect paints and veterinary and human medicine against many and veterinary and human medicine against many and demodicidosis. Its use is controlled, particularlybecause of neurological toxicity
[IARC]

1 (Vol. 113) 2018
[NIST Chemistry Reference]

Lindane(58-89-9)
[EPA Substance Registry System]

Cyclohexane, 1,2,3,4,5,6-hexachloro-, (1.alpha.,2.alpha.,3.beta., 4.alpha.,5.alpha.,6.beta.)- (58-89-9)
Hazard InformationBack Directory
[Chemical Properties]

white powder
[Uses]

Insecticide.
[General Description]

Colorless solid with a musty odor; pure material is odorless. Used as a pesticide and scabicide.
[Air & Water Reactions]

Insoluble in water.
[Reactivity Profile]

LINDANE is incompatible with strong bases. LINDANE is incompatible with powdered metals such as iron, zinc and aluminum. LINDANE is also incompatible with oxidizing agents. LINDANE can undergo oxidation when in contact with ozone. When exposed to alkalis, LINDANE undergoes dehydrochlorination.
[Health Hazard]

LINDANE is a stimulant of the nervous system, causing violent convulsions that are rapid in onset and generally followed by death or recovery within 24 hours. The probable human oral lethal dose is 50-500 mg/kg, or between 1 teaspoon and 1 ounce for a 150-lb (70 kg) person.
[Fire Hazard]

When heated to decomposition, LINDANE emits toxic fumes of chlorine, hydrochloric acid, and phosgene.
[Potential Exposure]

The major commercial usage of BHC is based upon its insecticidal properties. α-BCH is used as an Agricultural chemical, pesticide, pharmaceutical, and veterinary drug. The 7-isomer has the highest acute toxic ity, but the other isomers are not without activity. It is gen erally advantageous to purify the 7-isomer from the less active isomers. The γ-isomer acts on the nervous system of insects, principally at the level of the nerve ganglia. As a result, lindane has been used against insects in a wide range of applications including treatment of animals, buildings, humans for ectoparasites, clothes; water for mosquitoes; living plants; seeds and soils. Some applications have been abandoned due to excessive residues, e.g., stored food stuffs. By voluntary action, the principal domestic producer of technical grade BHC requested cancellation of its BHC registrations on September 1, 1976. As of July 21, 1978, all registrants of pesticide products containing BHC voluntar ily canceled their registrations or switched their former BHC products to lindane formulations.
[First aid]

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 30 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Speed in removing material from skin is of extreme importance. Shampoo hair promptly if con taminated. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medi cal attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
[Shipping]

UN2761 Organochlorine pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
[Incompatibilities]

Lindane decomposes on contact with powdered iron, aluminum, and zinc and with alkalis producing trichlorobenzene. Corrosive to metals
[Description]

Lindane is one of eight different hexachlorocyclohexane (HCH), [58-89-9], C6H6Cl6, isomers and its Chemical Abstract name is 1α, 2α,3β,4α,5α,6β- hexachlorocyclohexane 58-89-9 (γ-HCH or γ -BHC, benzene hexachloride) (80). Commercial products containing lindane are marketed as either a mixture of isomers or as the pure γ -BHC isomer. Not unexpectedly, lindane is a highly stable lipophilic compound and it has been used extensively worldwide as an insecticide. In contrast, hexachloropentadiene, [77-47-4], C5Cl6, is an extremely reactive industrial intermediate used as a chemical intermediate in the synthesis of a broad range of cyclodiene-derived pesticides, which include endosulfan, endrin, heptachlor, and several different organohalogen flame retardants (81).
[Waste Disposal]

For the disposal of lindane, a process has been developed involving destructive pyrolysis @ 400-500℃ with a catalyst mixture which contains 5%-10% of either cupric chloride, ferric chloride; zinc chloride; or aluminum chloride on activated carbon. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
[Physical properties]

Colorless to yellow crystalline solid with a slight, musty, chlorinated-like odor. Odor threshold concentration is 12.0 mg/kg (Sigworth, 1964). Robeck et al. (1965) reported an odor threshold of 330 ppb.
[Originator]

Kwell,Reed Carnrick,US,1952
[Definition]

ChEBI: Beta-hexachlorocyclohexane is the beta-isomer of hexachlorocyclohexane. It has a role as a persistent organic pollutant. It is an organochlorine pesticide and a hexachlorocyclohexane.
[Indications]

Lindane (Gamma benzene hexachloride, Kwell, Thionex) is a cyclic chlorinated hydrocarbon originally developed as an agricultural insecticide. It is absorbed through the chitinous exoskeleton and stimulates the nervous system, resulting in seizures and death of the insect. It is both a pediculicide and scabicide, with a 45% to 70% ovicidal effect. Resistance has been shown to Pediculosis capitis and Sarcoptes scabiei.
Lindane can be absorbed through intact skin following topical application and has the potential for CNS toxicity. It should therefore be used with great caution in infants, children <2 years of age, elderly patients, and pregnant and lactating women. It may be irritating to the eyes or mucous membranes; hence, these areas should be avoided. Irritant dermatitis may occur with use of excessive amounts or over prolonged periods. Toxicity, if overused, may result in nausea, vomiting, seizures, or even bone marrow suppression.
Lindane is an organochlorine with very slow onset of action and poor ovicidal activity; it takes over 3 hours to kill the lice during which increased lice crawling and twitching can cause increased pruritus for the patient. Lindane is available as a shampoo for the treatment of pediculosis capitis and/or pubis and in cream and lotion form for treating scabies and all forms of pediculosis. GBH also repels ticks and other arthropods and kills chiggers.
[Manufacturing Process]

Chlorine gas was gradually passed into 660 parts of benzene contained in a lead-lined reaction vessel until 890 parts of the gas had been absorbed. The mixture was stirred continuously and the temperature maintained at 15°C to 20°C.
The supply of chlorine was then interrupted and the precipitated solid filtered off and dried. In weight, it was found to be equivalent to 900 parts. The mother liquid was then mixed with 330 parts of benzene and the mixture again treated with 890 parts of chlorine in the manner described.
After filtering the reaction mixture resulting from the second chlorination, the filtrate was again mixed with a smaller quantity of benzene and again chlorinated in a similar manner. In this way, a continuous process for the preparation of benzene hexachloride resulted.
That benzene hexachloride isomer mixture is then the raw material for lindane production. The production of lindane per se is not a chemical synthesis operation but a physical separation process. It is possible to influence the gamma isomer content of benzene hexachloride to an extent during the synthesis process. Basically, however, one is faced with the problem of separating a 99%-plus purity gamma isomer from a crude product containing perhaps 12 to 15% of the gamma isomer. The separation and concentration process is done by a carefully controlled solvent extraction and crystallization process. One such process is described by R.D. Donaldson et al. Another description of hexachlorocyclohexane isomer separation is given by R.H. Kimball.
[Brand name]

Benhexachlor;Gamex;Gamma benzene;Hexachloride.
[Therapeutic Function]

Pediculicide, Scabicide
[World Health Organization (WHO)]

Lindane has been available for more than 25 years and is widely used as an agricultural and household pesticide.
[Agricultural Uses]

Insecticide, Rodenticide: Lindane has been used against insects in a wide range of applications including treatment of animals, buildings, man for ectoparasites, clothes, water for mosquitoes, living plants, seeds and soils. Most applications have been canceled due to excessive residues, e.g., stored foodstuffs, that may cause cancer. Formulators, distributors and users of lindane represent a special risk group. The major use of lindane in recent years has been to pretreat seeds. Other uses include sunflowers, peas, wheat, barley and oats. Lindane is currently also used in lotions, creams and shampoos for the control of lice and mites in humans. Not approved for use in EU countries. A U.S. EPA restricted Use Pesticide (RUP). Lindane should be handled as a carcinogen, with extreme caution. Most applications have been canceled. It has not been produced in the U.S. since 1977; however, it is still imported into the U.S. and formulated to treat head lice, body lice and scabies.
[Trade name]

AALINDAN®; AFICIDE®; AGRISOL G-20®; AGROCIDE®; AGRONEXIT®; AMEISENATOD®; AMEISENMITTEL (MERCK)®; APARASIN®; APHTIRIA®; APLIDAL®; ARBITEX®; BEN-HEX®; BENTOX 10®; CELANEX®; CHLORESENE®; CODECHINE®; DELSANEX DAIRY FLY SPRAY®; DETMOL-EXTRAKT®; DETOX 25®; DEVORAN®; DOL GRANULE®; DRILL TOXSPEZIAL AGLUKON®; DUAL MURGANIC RPB SEED TREATMENT®; ENTOMOXAN®; EXAGAMA®; FORLIN®; GALLOGAMA®; GAMACID®; GAMAPHEX®; GAMENE®; GAMMA-COL®; GAMMALIN®; GAMMALIN 20; GAMMALEX®; GAMMASAN 30®; GAMMATERR®; GAMMAPHEX®; GAMMEX®; GAMMEXANE®; GAMMEXENE®; GAMMOPAZ®; GEXANE®; HECLOTOX®; HEXA®; HEXAFLOW®; HEXATOX®; HEXAVERM®; HEXICIDE®; HEXYCLAN®; HORTEX®; INEXIT®; ISOTOX®; JACUTIN®; KOKOTINE®; KWELL®; LENTOX®; LINDAGRAM®; LIDENAL®; LINDAFOR®; LINDAGAM®; LINDAGRAIN®; LINDAGRANOX®; LINDAPOUDRE®; LINDATOX®; LINDOSEP®; LINTOX®; LOREXANE®; MARSTAN FLY SPRAY®; MERGAMMA 30®; MILBOL 49®; MIST-O-MATIC LINDEX®; MSZYCOL®; NEXEN FB®; NEXIT®; NEXIT-STARK®; NEXOL-E®; NICOCHLORAN®; NOVIGAM®; OMNITOX®; OVADZIAK®; OWADZIAK®; PEDRACZAK®; PFLANZOL®; QUELLADA®; RODESCO INSECT POWDER®; SANG GAMMA®; SILVANO®; SPRITZ-RAPIDIN®; SPRUEHPFLANZOL®; STREUNEX®; TAP 85®; TRI- 6®; VITON®
[Clinical Use]

Lindane is 1,2,3,4,5,6-hexachlorocyclohexane, -benzenehexachloride, or benzene hexachloride (Kwell, Scabene,Kwildane, G-Well). This halogenated hydrocarbon is preparedby the chlorination of benzene. A mixture of isomersis obtained in this process, five of which have been isolated:α, β, γ, δ, and ε. The γ-isomer, present to 10% to 13% inthe mixture, is responsible for the insecticidal activity. The -isomer may be separated by various extraction and chromatographictechniques.Lindane occurs as a light buff to tan powder with a persistentmusty odor, and it is bitter. It is insoluble in water butsoluble in most organic solvents. It is stable under acidic orneutral conditions but undergoes elimination reactions underalkaline conditions.The action of lindane against insects is threefold: it is a directcontact poison, it has a fumigant effect, and it acts as astomach poison. The effect of lindane on insects is similar tothat of DDT. Its toxicity in humans is somewhat lower thanthat of DDT. Because of its lipid solubility properties, however,lindane when ingested tends to accumulate in the body.Lindane is used locally as a cream, lotion, or shampoo forthe treatment of scabies and pediculosis.
[Carcinogenicity]

Lindane (as γ-hexachlorocyclohexane), hexachlorocyclohexan e (technical grade), and other hexachlorocyclohexane isomers are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals.
[Environmental Fate]

Biological. In a laboratory experiment, a strain of Pseudomonas putida culture transformed lindane to g-3,4,5,6-tetrachlorocyclohexane (g-TCCH), g-pentachlorocyclohexane (g-PCCH) and a-BHC (Benezet and Matsumura, 1973). g-TCCH was also reported as a product of lindane degradation by Clostridium sphenoides (MacRae et al., 1969; Heritage and MacRae, 1977, 1977a), an anaerobic bacterium isolated from flooded soils (MacRae et al., 1969; Sethunathan and Yoshida, 1973a). Lindane degradation by Escherichia coli also yielded g-PCCH (Francis et al., 1975). Evidence suggests that degradation of lindane in anaerobic cultures or flooded soils amended with lindane occurs via reductive dehalogenation producing chlorine-free volatile metabolites (Sethunathan and Yoshida, 1973a).
After a 30-day incubation period, the white rot fungus Phanerochaete chrysosporium converted lindane to carbon dioxide. Mineralization began between the third and sixth day of incubation. The production of carbon dioxide was highest between 3 to 18 days o
Beland et al. (1976) studied the degradation of lindane in sewage sludge under anaerobic conditions. Lindane underwent reductive hydrodechlorination forming 3,4,5,6-tetrachlorocyclohex- 1-ene (g-BTC). The amount of g-BTC that formed reached a maximum conc
When lindane was incubated in aerobic and anaerobic soil suspensions for 3 weeks, 0 and 63.8% was lost, respectively (MacRae et al., 1984). Using settled domestic wastewater inoculum, lindane (5 and 10 mg/L) did not degrade after 28 days of incubation at 25°C (Tabak et al., 1981).
Soil. In moist soils, lindane biodegraded to g-pentachlorocyclohexene (Elsner et al., 1972; Kearney and Kaufman, 1976; Fuhremann and Lichtenstein, 1980). Under anaerobic conditions, degradation by soil bacteria yielded g-BTC and a-BHC (Kobayashi
[Metabolic pathway]

The metabolic pathways of gamma-HCH are complex and more than 80 metabolites have been identified (Macholz and Kujawa, 1985). Dehydrohalogenation reactions are important. Gamma-HCH may be converted into other HCH isomers in the environment and also microorganisms and plants may convert gamma-HCH (1) into the alpha (2), beta (3), or delta (4) isomers (see Schemel). Bioisomerisation does not appear to be a significant pathway in mammals. In animals, metabolism of gamma-HCH generally leads to less-chlorinated, unsaturated metabolites. Chlorinated phenols may be formed and excreted as glucuronides. In a detailed discussion of the biodegradation of gamma-HCH, the reaction mechanisms involved were critically reviewed (Kurihara and Nakajima, 1980). Oxygenation or glutathione conjugation are important initial stages in metabolism. Key intermediates in the metabolic pathways are hexachlorocyclohexene (18), pentachlorocyclohexene (5) and tetrachlorocyclohexene (6) and these have been identified in a number of organisms (Macholz and Kujawa, 1985).
[Solubility in water]

Wt % at 20 °C: 30.31 in acetone, 22.42 in benzene, 19.35 in chloroform, 17.22 in ether, 6.02 in ethanol (Windholz et al., 1983)
9.76 and 13.97 g/L in hexane at 10 and 20 °C, respectively (shake flask-GC, Mills and Biggar, 1969)
92.8 g/kg in triolein at 25 °C (Chiou and Manes, 1986)
[storage]

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly sealed containers in a cool, dryplace away from light and incompatible materials. Protectcontainers against physical damage. A regulated, markedarea should be established where this chemical is handled,used, or stored in compliance with OSHA Standard1910.1045.
[Purification Methods]

Crystallise it from EtOH. Purify it also by zone melting. Possible CANCER AGENT, TOXIC. [: Beilstein 1 H 23, : Beilstein 5 I 8, many isomers : Beilstein 5 III 41, 5 IV 55.]
[Degradation]

Gamma-HCH is extremely stable to light, air, temperatures up to 180 °C, and to acids. It undergoes dechlorination in alkalis with DT50 values (22 °C) of 191 days (pH 7) and 11 hours (pH 9). It is photodegraded in organic solvents (2-propanol or methanol) by UV irradiation (254 nm).
[Toxicity evaluation]

The acute toxicity of lindane depends on the age, sex, and animal species, and on the route of administration. The oral LD50 in mice, rats, and guinea pigs is 86, 125–230, and 100–127 mg/kg, respectively. In contrast, most of the other isomers were considerably more toxic (94,95). Some of the other toxic responses caused by lindane in laboratory animals include hepato- and nephrotoxicity, reproductive and embryotoxicity, mutagenicity in some short-term in vitro bioassays, and carcinogenicity (80). The mechanism of the lindane-induced response is not known. Only minimal data are available on the mammalian toxicities of hexachlorocyclopentadiene.
Safety DataBack Directory
[Hazard Codes ]

T,N,F,Xn,Xi
[Risk Statements ]

20/21-25-48/22-50/53-64-39/23/24/25-23/24/25-11-67-65-38-52/53-62-48/20-40-21
[Safety Statements ]

36/37-45-60-61-62-33-29-16-9-7-22
[RIDADR ]

UN 2811 6.1/PG 1
[WGK Germany ]

3
[RTECS ]

GV4900000
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[HS Code ]

2903810000
[Safety Profile]

Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. A human systemic poison by ingestion. Also a poison by ingestion, skin contact, intraperitoneal, intravenous, and intramuscular routes. Human systemic effects by ingestion: convulsions, dyspnea, and cyanosis. Experimental teratogenic and reproductive effects. Mutation data reported. See also BENZENE HEXACHLORIDE and other benzene hexachloride entries. When heated to decomposition it emits toxic fumes of Cl-, HCl, and phosgene.
[Hazardous Substances Data]

58-89-9(Hazardous Substances Data)
[Toxicity]

LD50 in male, female rats (mg/kg): 88, 91 orally (Gaines)
[IDLA]

50 mg/m3
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Benzene-->Chlorine-->Tetrachlorvinphos-->CYCLOHEXANE-D12-->BETA-HCH-->CHLORDENE
Spectrum DetailBack Directory
[Spectrum Detail]

LINDANE(58-89-9)MS
LINDANE(58-89-9)1HNMR
LINDANE(58-89-9)13CNMR
LINDANE(58-89-9)IR1
LINDANE(58-89-9)IR2
LINDANE(58-89-9)Raman
58-89-9 suppliers list
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Website: www.chemicalbook.com/ShowSupplierProductsList1549548/0.htm
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674; , 15093356674;
Website: http://www.coreychem.com
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 0551-65418671
Website: https://www.tnjchem.com
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250 , +86-15129568250
Website: www.dideu.com
Company Name: AFINE CHEMICALS LIMITED
Tel: 0571-85134551
Website: www.afinechem.com/index.html
Company Name: GIHI CHEMICALS CO.,LIMITED
Tel: +8618058761490 , +8618058761490
Website: https://www.gihichemicals.com/
Company Name: LGC Standards
Tel: +44 (0)20 8943 8480
Website: www.lgcstandards.com
Company Name: Super Crop Safe Limited  
Tel: +91-9726022444 +91-9824169514
Website: www.www.NOWEBSITE
Company Name: Mainchem Co., Ltd.  
Tel: +86-0592-6210733
Website: https://www.mainchem.com
Company Name: Chemwill Asia Co.,Ltd.  
Tel: 86-21-51086038
Website: www.chemwill.com
Company Name: Shaanxi Didu New Materials Co. Ltd  
Tel: +86-89586680 +86-13289823923
Website: www.dideu.com/en/
Company Name: Suzhou Philip Johnson Pharmaceutical Co., Ltd  Gold
Tel: 0512-82780333-8506
Website: www.homesunpharm.com
Company Name: BEST-REAGENT  
Tel: 400-1166-196 18981987031
Website: http://www.hx-r.com/
Company Name: Spectrum Chemical Manufacturing Corp.  
Tel: 021-021-021-67601398-809-809-809 15221380277
Website: www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us
Company Name: Chengdu Ai Keda Chemical Technology Co., Ltd.  
Tel: 4008-755-333 18080918076
Website: http://www.aikeshiji.com
Company Name: TOKYO CHEMICAL INDUSTRY CO., LTD.  
Tel: 03-36680489
Website: https://www.tcichemicals.com/ja/jp/index.html
Company Name: 9ding chemical ( Shanghai) Limited  
Tel: 4009209199
Website: www.9dingchem.com
Tags:58-89-9 Related Product Information
14233-37-5 105601-04-5 46503-52-0 141-03-7 118-74-1