| Identification | Back Directory | [Name]
tertiapin | [CAS]
58694-52-3 | [Synonyms]
Tertiapin(reduced)
L-Lysinamide, L-alanyl-L-leucyl-L-cysteinyl-L-asparaginyl-L-cysteinyl-L-asparaginyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-isoleucyl-L-prolyl-L-histidyl-L-methionyl-L-cysteinyl-L-tryptophyl-L-lysyl-L-lysyl-L-cysteinylglycyl-L-lysyl- | [Molecular Formula]
C106H180N34O23S5 | [MDL Number]
MFCD02094633 | [MOL File]
58694-52-3.mol | [Molecular Weight]
2459.1 |
| Hazard Information | Back Directory | [Uses]
Tertiapin (reduced) is a kind of synthesis of melittin, its Cys3-Cys14 and Cys5-Cys18 between containing a disulfide bond. Tertiapin (reduced) is a kind of inward rectifier potassium channels blockers, can block the activity of calcium activates large conductance potassium channels. Tertiapin (reduced) can be used for research in diseases such as rheumatoid arthritis and multiple sclerosis[1]. | [References]
[1] Kitamura H, et al. Tertiapin potently and selectively blocks muscarinic K+ channels in rabbit cardiac myocytes[J]. Journal of Pharmacology and Experimental Therapeutics, 2000, 293(1): 196-205. PMID:10734170 |
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