| Identification | Back Directory | [Name]
LICOCHALCONEB | [CAS]
58749-23-8 | [Synonyms]
LICOCHALCONEB
Licoagrochalcone B
3,4,4'-Trihydroxy-2-Methoxychalcone
3,4,4'-Trihydroxy-2-methoxy-trans-chalcone
(E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one
2-Propen-1-one,3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)- | [Molecular Formula]
C16H14O5 | [MDL Number]
MFCD20527294 | [MOL File]
58749-23-8.mol | [Molecular Weight]
286.28 |
| Chemical Properties | Back Directory | [Melting point ]
196-197℃ | [Boiling point ]
550.5±50.0 °C(Predicted) | [density ]
1.369±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
7.80±0.15(Predicted) | [color ]
White | [biological source]
plant | [Water Solubility ]
water: slightly soluble | [Major Application]
metabolomics
vitamins, nutraceuticals, and natural products | [InChI]
InChI=1S/C16H14O5/c1-21-16-11(5-9-14(19)15(16)20)4-8-13(18)10-2-6-12(17)7-3-10/h2-9,17,19-20H,1H3/b8-4+ | [InChIKey]
DRDRYGIIYOPBBZ-XBXARRHUSA-N | [SMILES]
C(C1=CC=C(O)C=C1)(=O)/C=C/C1=CC=C(O)C(O)=C1OC |
| Hazard Information | Back Directory | [Chemical Properties]
LICOCHALCONEB is a yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents,and it is derived from licorice rhizomes. | [Uses]
LICOCHALCONEB has anti-tumor, anti-inflammatory, and antioxidant effects.It can be used for content determination, identification, pharmacological experiments, etc. | [Definition]
ChEBI: Licochalcone B is a member of chalcones. | [Biological Activity]
LICOCHALCONEB is extracted from Glycyrrhizainflate root. LICOCHALCONEB inhibits the self-aggregation of amyloid β (Aβ420) (IC50=2.16 μM) and disintegrates pre-formed Aβ42 fibrils, reducing metal-induced Aβ42 aggregation by chelating metal ions. | [in vivo]
Licochalcone B (1-25 mg/kg, oral gavage) alleviates oxidative stress of hepatotoxicity in mice induced by CCl4[5].
| Animal Model: | Mice induced by CCl4[5] | | Dosage: | 1, 5, 25 mg/kg | | Administration: | Oral gavage. | | Result: | Elevated the levels of SOD and GSH, and reduced the GSSG levels. |
| [IC 50]
NLRP3 |
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