| Identification | Back Directory | [Name]
Licochalcone E | [CAS]
864232-34-8 | [Synonyms]
Licochalcone E
2-Propen-1-one, 3-[5-[(1S)-1,2-dimethyl-2-propen-1-yl]-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-, (2E)- | [Molecular Formula]
C21H22O4 | [MDL Number]
MFCD32693964 | [MOL File]
864232-34-8.mol | [Molecular Weight]
338.4 |
| Chemical Properties | Back Directory | [Melting point ]
76-80 °C | [Boiling point ]
543.745±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.172±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO: 125 mg/mL (369.39 mM) | [form ]
Solid | [pka]
7.823±0.15(predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the rhizome of Glycyrrhiza uralensis Fisch. | [Uses]
Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation[1]. | [Biological Activity]
Licochalcone E, a flavonoid extracted from Glycyrrhiza inflate, inhibits the transcriptional activity of NF-κB and AP-1 by inhibiting the activation of AKT and MAPK. | [target]
| [storage]
4°C, protect from light | [References]
[1] Lee HN, et al. Mechanisms by which licochalcone e exhibits potent anti-inflammatory properties: studies with phorbol ester-treated mouse skin and lipopolysaccharide-stimulated murine macrophages. Int J Mol Sci. 2013 May 24;14(6):10926-43. DOI:10.3390/ijms140610926 |
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