| Identification | More | [Name]
N,N-DIETHYLNICOTINAMIDE | [CAS]
59-26-7 | [Synonyms]
ANACARDONE
CORVOTONE
DYNACORYL
EUCORAN
LABOTEST-BB LT00134638
NICAMIDE
NICKETHAMIDE
NICOTINIC ACID DIETHYLAMIDE
NIKETHAMIDE
NIKETHAMIDUM
N,N-DIETHYLNICOTINAMIDE
PYRICARDYL
PYRIDINE-3-CARBOXYLIC ACID DIETHYLAMIDE
3-Pyridinecarboxamide, N,N-diethyl-
Anacordone
Astrocar
beta-Pyrimidum
Camphozone
Canfodiamina
Carbamidal | [EINECS(EC#)]
200-418-5 | [Molecular Formula]
C10H14N2O | [MDL Number]
MFCD00006386 | [Molecular Weight]
178.23 | [MOL File]
59-26-7.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to yellow liquid | [Melting point ]
23 °C (lit.) | [Boiling point ]
296-300 °C (lit.) | [density ]
1.06 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.524(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Liquid | [pka]
pKa 3.46(H2O,t =20) (Uncertain) | [color ]
Clear colorless to yellow | [Merck ]
6543 | [BRN ]
5743 | [InChI]
InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3 | [InChIKey]
NCYVXEGFNDZQCU-UHFFFAOYSA-N | [SMILES]
C1=NC=CC=C1C(N(CC)CC)=O | [CAS DataBase Reference]
59-26-7(CAS DataBase Reference) | [EPA Substance Registry System]
Nikethamide (59-26-7) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301-H319 | [Precautionary statements ]
P264-P270-P280-P301+P310-P305+P351+P338-P337+P313 | [Hazard Codes ]
T | [Risk Statements ]
R25:Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
QS4375000
| [REACH Registrations]
Active | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29333999 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Irrit. 2 | [Safety Profile]
Poison by ingestion,
intravenous, intraperitoneal, and
subcutaneous routes. When heated to
decomposition it emits toxic fumes of NOx.
| [Toxicity]
LD50 i.p. in rats: 272 mg/kg (Goldenthal) |
| Hazard Information | Back Directory | [General Description]
Clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth. | [Reactivity Profile]
NICETHAMID(59-26-7) is incompatible with sodium carbonate solutions which cause precipitation. . | [Air & Water Reactions]
Water soluble. | [Health Hazard]
ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. | [Fire Hazard]
This chemical is combustible. | [Description]
A further Corydalis alkaloid, coramine has been obtained from C. pseudoadunca
M. Pop. It forms colourless needles from EtOH and is optically active with a
specific rotation of [α]D - 391 ° (c 0.2, MeOH). Both the hydrochloride, m.p.
216-9°C and the hydrobromide, m.p. 223-6°C have been described. | [Chemical Properties]
clear colorless to yellow liquid | [Uses]
analeptic | [Application]
N,N-Diethylnicotinamide (DENA) is one of the central respiratory stimulants and is used in the study of respiratory failure. DENA is also an excellent hydrophilic agent for paclitaxel (PTX) and improves the water solubility of PTX. | [Definition]
ChEBI: Nikethamide is a pyridinecarboxamide. It is functionally related to a nicotinamide. | [storage]
Store at -20°C | [References]
Yunusov, Akramov, Yunusov, Dokl. Akad. Nauk. USSR, 162,607 (1965)
Yunusov, Akramov, Yunusov, Khim. Prir. Soedin., 2, 340 (1966)
Ibragimova, Yunusov, Yunusov, ibid, 6,438 (1970)
Yunusov, et al., ibid, 7, 380 (1971) |
|
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Sigma-Aldrich
|
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021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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Boen pharm
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86 512-62572107 62962707 |
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www.chemicalbook.com/ShowSupplierProductsList19300/0_EN.htm |
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