| Identification | Back Directory | [Name]
CP-640186 (hydrochloride) | [CAS]
591778-70-0 | [Synonyms]
CS-1253
CP640186 HCl
CP-640186 (hydrochloride)
CP-640186 hydrochloride, >=98%
(3R)-1'-(anthracene-9-carbonyl)-3-(morpholine-4-c
arbonyl)-1,4'-bipiperidine hydrochloride
(R)-ANTHRACEN-9-YL(3-(MORPHOLINE-4-CARBONYL)-[1,4'-BIPIPERIDIN]-1'-YL)METHANONE HYDROCHLORIDE | [Molecular Formula]
C30H36ClN3O3 | [MDL Number]
MFCD28167776 | [MOL File]
591778-70-0.mol | [Molecular Weight]
522.09 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:39.0(Max Conc. mg/mL);74.7(Max Conc. mM)
H2O:50.0(Max Conc. mg/mL);95.77(Max Conc. mM) | [form ]
Solid | [color ]
Light yellow to pink | [Water Solubility ]
H2O: 2mg/mL, clear (warmed) |
| Hazard Information | Back Directory | [Uses]
CP 640186 Hydrochloride can be used as acetyl CoA carboxylase inhibitors against metabolic syndrome and other disorders. | [Biological Activity]
CP-640186 is a potent and orally active acetyl-CoA carboxylase 1/2 (ACC-alpha/betaACC1/2) inhibitor (IC50 ~50 nM) th at targets the carboxyltransferase (CT) domain at the ACC dimer interface (via tight interactions with the putative biotin-binding site) in a reversible manneruncompetitive with respect to ATPand non-competitive with respect to bicarbonateacetyl-CoAand citrate. CP-610431 inhibits fatty acid (FA) synthesistriglyceride (TG) synthesisTG and apoB secretion (IC50 = 1.61.83.0and 5.7 μMrespectively)but not cholesterol synthesis or apoC3 secretion in HepG2 cells (ACC1)as well as stimulates FA oxidation in C2C12 cells (ACC2) and in r at epitrochlearis muscle strips (EC50 = 57 nM and 1.3 μMrespectively). Oral administration is shown to inhibit FA synthesis in ratsCD1 miceand ob/ob mice (ED50 = 1311and 4 mg/kgrespectively) and stimulate r at whole body FA oxidation (ED50 ∼30 mg/kg) in vivo. |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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