| Identification | Back Directory | [Name]
Adenosine 5'-(trihydrogen diphosphate), 8-bromo-, P'→5-ester with D-ribose | [CAS]
59259-77-7 | [Synonyms]
Adenosine 5'-(trihydrogen diphosphate), 8-bromo-, P'→5-ester with D-ribose | [Molecular Formula]
C15H22BrN5O14P2 | [MOL File]
59259-77-7.mol | [Molecular Weight]
638.21 |
| Hazard Information | Back Directory | [Uses]
8-Br-ADPR (8-Bromoadenosine-5'-O-diphosphoribose), an analogue of Adenosine 5′-diphosphoribose (HY-100973), is a TRPM2 modulator. 8-Br-ADPR is a human TRPM2 (hsTRPM2) inhibitor and a Nematostella vectensis (nvTRPM2) partial agonist (EC50 of 31.9 μM). 8-Br-ADPR regulates calcium release from the endoplasmic reticulum and sarcoplasmic reticulum[1]. | [References]
[1] Tóth B, et al. Selective profiling of N- and C-terminal nucleotide-binding sites in a TRPM2 channel. J Gen Physiol. 2020 May 4;152(5):e201912533. DOI:10.1085/jgp.201912533 |
|
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
|