| Identification | Back Directory | [Name]
1-Methyl-2-undecyl-1,4-dihydroquinoline-4-one | [CAS]
59443-02-6 | [Synonyms]
1-METHYL-2-UNDECYLQUINOLIN-4(1H)
1-methyl-2-undecylquinolin-4-one
1-Methyl-2-undecyl-4(1H)-quinolone
1-Methyl-2-undecyl-4(1H)-quinolinone
1-Methyl-2-undecylquinolin-4(1H)-one
4(1H)-Quinolinone, 1-methyl-2-undecyl-
1-Methyl-2-undecyl-1,4-dihydroquinoline-4-one | [Molecular Formula]
C21H31NO | [MOL File]
59443-02-6.mol | [Molecular Weight]
313.48 |
| Hazard Information | Back Directory | [Uses]
1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of MAO-B activity with the IC50 and Ki values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS[1][2]. | [IC 50]
MAO-B: 15.3 μM (IC50); MAO-B: 9.91 μM (Ki) | [References]
[1] Toshiya K, et al. Isolation and Structure Elucidation of Three Quinolone
[2] Lee MK, et al. 1-methyl-2-undecyl-4(1H)-quinolone as an irreversible and selective inhibitor of type B monoamine oxidase. Chem Pharm Bull (Tokyo). 2003;51(4):409-411. DOI:10.1248/cpb.51.409 |
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