| Identification | Back Directory | [Name]
L-ERYTHRO-DIHYDROSPHINGOSINE | [CAS]
6036-76-6 | [Synonyms]
SPC-103980
L-ERYTHRO-SPHINGANINE
L-ERYTHRO-DIHYDROSPHINGOSINE
L-erythro Sphinganine (d18:0)
(2R,3S)-2-Amino-1,3-octadecanediol
1,3-Octadecanediol, 2-amino-, (2R,3S)- | [Molecular Formula]
C18H39NO2 | [MDL Number]
MFCD00274349 | [MOL File]
6036-76-6.mol | [Molecular Weight]
301.51 |
| Chemical Properties | Back Directory | [Boiling point ]
446.2±25.0 °C(Predicted) | [density ]
0.927±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO: 25 mg/mL warm | [form ]
A solid | [pka]
12.57±0.45(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Description]
L-erythro Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and D-threo sphinganine . It induces autophagy in HCT116 cells when used at a concentration of 12 μM. L-erythro Sphinganine induces cell cycle arrest of 7R4-LCB1 yeast cells. It is metabolized via sphinganine N-acyltransferase and sphinganine kinase in vivo in rat liver. [Matreya, LLC. Catalog No. 1846] | [Uses]
L-erythro-Dihydrosphingosine is an ester product. | [Definition]
ChEBI: Erythro-dihydrosphingosine is an amino alcohol. | [storage]
Store at -20°C | [References]
[1] JESSE COWARD. Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway.[J]. Autophagy, 2009, 5 2: 184-193. DOI: 10.4161/auto.5.2.7361
[2] G M JENKINS Y A H. Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.[J]. The Journal of Biological Chemistry, 2001, 276 11: 8574-8581. DOI: 10.1074/jbc.m007425200
[3] W STOFFEL K B. Stereospecificities in the metabolic reactions of the four isomeric sphinganines (dihydrosphingosines) in rat liver.[J]. Hoppe-Seyler’s Zeitschrift fur physiologische Chemie, 1973, 354 2: 169-181. DOI: 10.1515/bchm2.1973.354.1.169 |
|
| Company Name: |
Alfa Chemistry
|
| Tel: |
1-516-6625404 |
| Website: |
https://www.alfa-chemistry.com |
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
| Company Name: |
Leancare Ltd.
|
| Tel: |
+33 962096793 |
| Website: |
www.leancare.co.uk |
| Company Name: |
Matreya LLC
|
| Tel: |
814 359 5060 |
| Website: |
www.matreya.com |
|