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60748-45-0

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60748-45-0 Structure

60748-45-0 Structure
IdentificationBack Directory
[Name]

TOXIN II, ANEMONIA SULCATA
[CAS]

60748-45-0
[Synonyms]

As2
Av2
ATX II
rATX II
Toxin ATX-II
Neurotoxin 2
ANEMONE TOXIN II
seaanemonetoxinii
ATX II, ANEMONIA SULCATA
Anemonia viridis toxin 2
Anemonia sulcata toxin II
Toxin Ⅱ,Anemonia sulcata
TOXIN II, ANEMONIA SULCATA
Toxin II from Anemonia sulcata
Anemone Toxin II recombinant from Escherichia coli
Toxin II, Anemonia sulcata - CAS 60748-45-0 - Calbiochem
[Molecular Formula]

C213H329N63O61S6
[MDL Number]

MFCD00132437
[MOL File]

60748-45-0.mol
[Molecular Weight]

4940.67
Chemical PropertiesBack Directory
[storage temp. ]

−20°C
[form ]

lyophilized powder
[Sequence]

Gly-Val-Pro-Cys-Leu-Cys-Asp-Ser-Asp-Gly-Pro-Ser-Val-Arg-Gly-Asn-Thr-Leu-Ser-Gly-Ile-Ile-Trp-Leu-Ala-Gly-Cys-Pro-Ser-Gly-Trp-His-Asn-Cys-Lys-Lys-His-Gly-Pro-Thr-Ile-Gly-Trp-Cys-Cys-Lys-Gln (Disulfide bonds: Cys4-Cys44, Cys6-Cys34, Cys27-Cys45)
Safety DataBack Directory
[WGK Germany ]

3
[RTECS ]

CK4438200
[Toxicity]

LD50 ivn-mus: 310 mg/kg TOXIA6 16,561,78
Hazard InformationBack Directory
[Uses]

ATX-II is a specific Na+ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II causes delayed inactivation of the Na+Ryanodine (HY-103306). ATX-II also induces pulmonary vein arrhythmogenesis and atrial fibrillation[1][2].
[Safety Profile]

A deadly poison by intravenousand parenteral routes.
[References]

[1] Fletcher JE, et al. ATX II, a sodium channel toxin, sensitizes skeletal muscle to halothane, caffeine, and ryanodine. Anesthesiology. 1999 May;90(5):1294-301. DOI:10.1097/00000542-199905000-00012
[2] Lu YY, et al. ATX-II-induced pulmonary vein arrhythmogenesis related to atrial fibrillation and long QT syndrome. Eur J Clin Invest. 2012 Aug;42(8):823-31. DOI:10.1111/j.1365-2362.2012.02655.x
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