| Identification | Back Directory | [Name]
CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2 | [CAS]
60786-59-6 | [Synonyms]
TGOT
(THR4
GLY7)-OXYTOCIN
[THR4, GLY7] OT
[THR4, GLY7]-OXYTOCIN
thr(4)-gly(7)-oxytoci
3,3-DiallylthiacarbocyanineBromide
CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2
H-CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2
H-CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2, (DISULFIDE BOND)
Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 (Disulfide bridge Cys1-Cys6)
(Thr4,Gly7)-Oxytocin H-Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 (Disulfide bond)
Glycinamide, L-cysteinyl-L-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-L-cysteinylglycyl-L-leucyl-, cyclic (1→6)-disulfide | [Molecular Formula]
C39H61N11O12S2 | [MDL Number]
MFCD00076735 | [MOL File]
60786-59-6.mol | [Molecular Weight]
940.1 |
| Chemical Properties | Back Directory | [Boiling point ]
1489.4±65.0 °C(Predicted) | [density ]
1.265±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [form ]
Solid | [pka]
9.90±0.15(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels. [1][2]. | [in vivo]
(Thr4,Gly7)-Oxytocin (1 μM, direct intra-PVT infusion for 1 min) evokes depolarization on TGOT-responsive neurons in mice[1].
(Thr4,Gly7)-Oxytocin (100 ng, intracerebroventrical injection) increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats[3].
| Animal Model: | Swiss Webster mice [1] | | Dosage: | 1 μM | | Administration: | Intratracheal administration for 24 h | | Result: | Excited 34.3% of aPVT neurons, 57.6% of mPVT neurons, and 60.0% of pPVT neurons.
Increased the firing rate of TGOT-responsive PVT neurons in all subregions.
|
| [References]
[1] Lily R Barrett, et al. Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology. 2021 Apr;46(5):1045-1056. DOI:10.1038/s41386-021-00961-3
[2] Binqi Hu, et al. Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms. Cereb Cortex. 2021 Mar 31;31(5):2402-2415. DOI:10.1093/cercor/bhaa363
[3] M R Melis, et al. Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning. Regul Pept. 1997 Mar 26;69(2):105-11. DOI:10.1016/s0167-0115(97)00002-5 |
|
|