| Identification | Back Directory | [Name]
Oxytocin, monoacetate (salt) | [CAS]
6233-83-6 | [Synonyms]
Pitocin Acetate
Synpitan Acetate
Uteracon Acetate
Orasthin Acetate
Perlacton Acetate
Syntocinon Acetate
50-56-6 (free base)
Oxytocin Monoacetate
α-Hypophamine acetate
Oxytocin Identification
Oxytocic hormone acetate
Oxytocin, monoacetate (salt)
Oxytocin acetate (50-56-6 free base)
Oxytocin Identification (15 mg) (COLD SHIPMENT REQUIRED)
Α-HYPOPHAMINE ACETATE;OXYTOCIC HORMONE ACETATE;50-56-6 (FREE BASE) | [EINECS(EC#)]
228-347-5 | [Molecular Formula]
C2H4O2 | [MOL File]
6233-83-6.mol | [Molecular Weight]
60.052 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:44.0(Max Conc. mg/mL);41.23(Max Conc. mM)
Water:50.0(Max Conc. mg/mL);46.85(Max Conc. mM) | [form ]
A crystalline solid | [color ]
White to off-white | [Sequence]
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge:Cys1-Cys6) | [InChIKey]
DSZOEVVLZMNAEH-SIVBSZNNNA-N |
| Hazard Information | Back Directory | [Description]
Oxytocin acetate is an analog of oxytocin, a hormone that stimulates the uterus during labor. It is synthesized by chemically conjugation oxytocin with acetic acid. The stability of this molecule has been proven to be higher than that of oxytocin. This drug demonstrates a stronger binding affinity for the oxytocin receptor, which may be attributed to its increased molecular weight. Additionally, oxytocin acetate has been observed to increase levels of growth factors and fatty acids in tissues when administered intramuscularly, while also stimulating neurotransmission. It exhibits a shorter onset latency and a longer duration of action compared to other analogs. Apart from its medical applications, oxytocin acetate can also serve as a disinfectant in cosmetic use and as an amide-forming agent in organic synthesis reactions.
| [Chemical Properties]
White Solid | [Uses]
The principal uterus-contracting and lactation-stimulating hormone of the posterior pituitary gland. | [Mechanism of action]
The actions of oxytocin are mediated by a single G protein-coupled receptor distributed in many peripheral tissues and specific brain areas. Oxytocin secreted into the circulation stimulates uterine contractions during labor and stimulates milk ejection during lactation.
| [in vivo]
During the LMA task, rat core body temperature are modestly decreased. Oxytocin acetate (subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose) produces significantly greater hypothermia (at 0.3 mg/kg) than either saline or the two lower doses of oxytocin. Oxytocin at 0.3 mg/kg produces a significantly greater decrease in temperature than vehicle between 15-60 min post injection, whereas 0.1 mg/kg slightly decreases temperature at the 30 min time point only[1].Oxytocin acetate (0.1 mg/kg) engages in significantly more body sniffing and ano-genital sniffing compared with saline controls. It also increases the total time spent in social interaction (71.6±4.3 s), compared to those receiving vehicle (56.9±4.1 s)[1]. | Animal Model: | Fifty-six male Lister-hooded rats (150–200?g)[1] | | Dosage: | 0.1?mg/kg-0.3 mg/kg | | Administration: | Subcutaneous?injection; 0.1?mg/kg-0.3 mg/kg; single dose | | Result: | Produced significantly greater hypothermia (at 0.3 mg/kg) than the saline group. |
| [IC 50]
Human Endogenous Metabolite | [References]
[1] MOSTAFA GHASEMISARABBADIEH; Benjamín R S; Sveinbj?rn Gizurarson. The effect of trehalose, antioxidants, and acetate buffer concentration on oxytocin stability[J]. Journal of Peptide Science, 2021. DOI:10.1002/psc.3324. |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
TOSUN PHARM
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020-66392521-118 18922260391 |
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www.toref.cn/ |
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